Pneumonia
Conditions
Keywords
pneumonia
Brief summary
Retrospective Analysis of Clinical Characteristics and Prognostic Factors in Hospitalized Pneumonia Patients from April 2023 to April 2026. Background: Pneumonia remains the leading cause of death from infectious diseases in adults worldwide, with an increasingly severe disease burden exacerbated by population aging and the frequent emergence of drug-resistant bacteria; in China, severe pneumonia accounts for a striking 13.58% to 20.05% of hospitalized cases. In recent years, shifts in the pathogen spectrum (e.g., COVID-19, influenza A) and patient demographic characteristics have posed new challenges for clinical management. However, existing studies mostly focus on single pathogens or specific populations (e.g., ICU patients), lacking systematic analyses of the full-disease course characteristics of general hospitalized pneumonia patients. Furthermore, in the post-pandemic era, the clinical phenotypes, treatment responses, and prognostic factors of pneumonia may have evolved, necessitating evidence-based support from real-world data. This study aims to conduct a retrospective analysis to clarify the epidemiological characteristics, etiological distribution, and prognostic factors influencing current hospitalized pneumonia patients, thereby providing a basis for optimizing diagnosis and treatment strategies.
Interventions
None listed
Sponsors
Zhonghao Fang
Fifth Affiliated Hospital of Guangzhou Medical University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Age ≥ 18 years old; 2. Meet the diagnostic criteria for pneumonia (acute onset + new infiltrates on imaging); 3. Have a positive result from pathogen testing; 4. Time from onset to admission ≤ 72 hours (to ensure being in the acute phase of the disease); 5. Sign a written informed consent form. Inclusion criteria for the severe group: A diagnosis of "severe pneumonia" can be made if one of the main criteria or ≥ 3 of the secondary criteria are met. Main criteria: ① Tracheal intubation requiring mechanical ventilation ② Need for vasoactive drugs after active fluid resuscitation for septic shock Secondary criteria: * Respiratory rate ≥ 30 breaths/min * PaO₂/FiO₂ ≤ 250 mm Hg * Multiple lobe infiltrates * Confusion and/or disorientation ⑤ Blood urea nitrogen ≥ 20 mg/dL ⑥ Leukopenia (WBC \< 4×10⁹/L) * Thrombocytopenia (PLT \< 100×10⁹/L) * Decreased body temperature (central body temperature \< 36 ℃) ⑨ Hypotension requiring fluid resuscitation
Exclusion criteria
* 1\) Patients with severely lacking medical records; 2\) Those whose main manifestations are other non-infectious diseases (such as pulmonary edema, lung cancer, pulmonary embolism, etc.); 3) Those whose main diagnosis is active pulmonary tuberculosis, non-infectious interstitial lung disease, etc.; 4) Patients considered not applicable by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day all-cause mortality rate | 28 days after admission |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Symptomatic manifestations | 28 days after admission | Symptomatic manifestations (e.g., fever, cough, dyspnea) |
| Laboratory tests | 28 days after admission | Laboratory tests (including blood routine, liver and kidney function, etc.) |
| Imaging Examination | 28 days after admission | Imaging Examination: Radiological manifestations and image data from chest X-ray or CT scans |
| ICU Length of Stay | 28 days after admission | — |
| Duration of Mechanical Ventilation | 28 days after admission | — |
| Length of Hospital Stay | 28 days after admission | — |
| Comorbidities | 28 days after admission | Comorbidities, such as chronic obstructive pulmonary disease (COPD), diabetes mellitus, and cardiovascular diseases. |
| Demographic characteristics | 28 days after admission | Demographic data (age, sex, etc.) |
Countries
China
Contacts
CONTACTLiang Peng, Doctor
STUDY_DIRECTORZifeng Yang
The First Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed