Effect of Self-assembly Peptide With or Without Laser on Remineralization of Initial Carious

Effect of Self-assembly Peptide With or Without Laser Treatment on the Remineralization of Initial Carious Lesion. Randomized Controlled Clinical Trials. (An In-vivo Study)

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07574814

Enrollment

Registered

2026-05-08

Start date

2025-03-19

Completion date

2026-04-01

Last updated

2026-05-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Caries; Initial, Carious Lesion

Keywords

carious lesions,, laser, remineralization, CPP-ACP, self assembly peptide

Brief summary

This study aimed to asses the effect of different remineralizing agents on the initial carious lesions at diff rant after immediately after treatment (as baseline), six months and one year. Objectives: Evaluation of reminralizing effect of: 1. Self- assembly peptide 2. Nano-hydroxy apitite gel 3. CPP-ACP varnish With or without laser treatment at three times intervals, immediately after treatment (as baseline), six months and one year

Detailed description

This study aimed to asses the effect of different remineralizing agents ( self-assembly peptide, nanohydroxy apitite gel and CPP-ACP varnish) with or without laser surface treatment on the initial carious lesions after immediately after treatment (as baseline), six months and one year using detecting device.

Interventions

RADIATIONER-CR Laser

ER-CR laser was applied for 10 sec in non-contact mode, at a distance of two mm, with pulse duration of 60 microsecond at four-Watt energy (80% water 60% air), 50 Hz energy.

OTHERWithout ER-CR Laser

ER-Cr laser was not used before the application of reminaralizing agents

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 35 Years

Healthy volunteers

Inclusion criteria

between 18 and 35 years of age, active carious (ICDAS), had received conventional manual periodontal therapy, had no systemic diseases or concomitant medication affecting salivary flow. \-

Exclusion criteria

Participant in another trial, non-carious lesion (enamel hypoplasia and dental fluorosis), Presence of abnormal oral, medical, or mental condition. Participants who had evidence of reduced salivary flow or significant tooth wear, also who had allergy to MI paste. \-

Design outcomes

Primary

Measure	Time frame	Description
Quantitative assessment of initial carious activity in numerical value using DIAGNOdent ( laser fluorescence detecting device )	1 year	Assessment of initial carious activity after using three different reminralizing agents with \\ without laser pre treatment using DIAGNOdent laser fluorescence detecting device

Countries

Egypt

Contacts

PRINCIPAL_INVESTIGATORMohamed Galal Elkholy

Azhar University, Cairo, Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: May 9, 2026