Cerebral Palsy (CP), Spastic Cerebral Palsy (sCP), Unilateral Cerebral Palsy
Conditions
Keywords
Cerebral Palsy, Spasticity, tDCS
Brief summary
Unilateral spastic cerebral palsy (USCP) is the most common subtype of cerebral palsy and significantly limits upper limb function. Traditional therapies such as constraint-induced movement therapy (CIMT) and bimanual intensive training offer limited benefits. Pharmacologic treatments often produce behavioral side effects and do not address underlying neuro-plastic deficits. There is an unmet need for safe, effective, non-invasive interventions targeting motor recovery through cortical modulation.
Interventions
OTHERAnodal tDCS
Anodal tDCS will be applied to the affected motor cortex area for 20 minutes along with the bimanual motor training. The intervention will be applied for 5 days in 1-2 weeks.
OTHERSham tDCS
Sham tDCS will be applied to the affected motor cortex for 20 minutes along with the bimanual motor training. The intervention will be applied for 5 days in 1-2 weeks.
Sponsors
Riphah International University
King Fahad Specialist Hospital Dammam
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
6 Years to 17 Years
Healthy volunteers
No
Inclusion criteria
1. Children aged 6-17 years with unilateral spastic CP 2. Wrist extension ≥ 20°, MCP/PIP joints ≥ 10°
Exclusion criteria
1. Any other neurological disorders 2. An orthopedic condition affecting the participation in UE activities. 3. Unable to understand the command.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ABILHAND-KIDS | baseline, after 1 week of intervention | ABILHAND-Kids is used to measure a child's manual ability (using their hands/arms) for daily tasks, especially for children with conditions like cerebral palsy or brachial plexus birth injury. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Box and Block test | Baseline, after 1 week of intervention | The Box and Block Test (BBT) assesses gross manual dexterity in kids with Cerebral Palsy (CP) aged 6-15 by having them move as many 1-inch blocks as possible from one box side to another in 60 seconds, one block at a time, testing each hand separately |
| Movement-related cortical potentials | baseline, 1 week after intervention | Movement-related cortical potentials (MRCP) with the help of EEG: peak amplitude, onset latency, and area under the curve at Cz/C3/C4. |
| Event-related desynchronization (ERD) / synchronization (ERS) | baseline, 1 week after intervention | Event-related desynchronization (ERD) / synchronization (ERS) with the help of EEG: mu (8-13 Hz) and beta (13-30 Hz) ERD magnitude and timing during movement. |
| Resting-state sensorimotor beta/mu power | baseline, 1 week after intervention | Resting-state sensorimotor beta/mu power with the help of EEG: absolute and relative power at C3/C4 and central ROI. |
| NIH Toolbox Cognitive and Emotional Scores | baseline, 1 week after intervention | The NIH Toolbox for the Assessment of Neurological and Behavioral Function (NIH Toolbox) is a set of standardized measures used by researchers and clinicians to assess motor, cognitive, emotional, and sensory functions. |
Countries
Pakistan
Contacts
CONTACTMirza Obaid Baig Assistant Professor, MS
PRINCIPAL_INVESTIGATORMirza Obaid Baig, MS
Riphah International University
Outcome results
None listed