Acute Decompensated Heart Failure
Conditions
Brief summary
The purpose of this study is to examine shorter hospitalization length as well as a reduced rates of recurrent heart failure hospitalization compared to current standard of care in Acute Decompensated Heart Failure. A 1-day reduction in hospital length of stay in unblinded subjects receiving daily HF-FOCUS examinations compared to a blinded standard of care arm.
Interventions
DIAGNOSTIC_TESTLung Ultrasound
Patients will undergo lung ultrasound assessments at hospital admission, daily throughout admission, and at hospital discharge.
Sponsors
Mayo Clinic
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Subjects ≥18 years of age * Admitted to St. Mary's Hospital Cardiology Progressive Care Unit (Cardiology 1-5 teams) * Admission diagnosis of either: 1. Acute systolic heart failure 2. Acute on chronic systolic heart failure 3. Acute diastolic heart failure 4. Acute on chronic diastolic heart failure 5. Acute right heart failure 6. Acute on chronic right heart failure 7. Failure heart biventricular * Able to provide informed consent and willing to undergo daily lung ultrasound examinations during their hospitalization.
Exclusion criteria
* Subjects \<18 years of age * Unable to provide informed consent. * Unwilling to undergo daily lung ultrasound examinations.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of days in the hospital | Baseline | The number of days a patient is in the hospital will be determined by the day of admission and day of discharge. The day of discharge will be defined as when the consultant physician states that the patient is medically ready for discharge from the hospital. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of re-hospitalized patients | Baseline | Number of patients re-hospitalized will be determined by the number of patients admitted to the hospital post discharge |
| Number of deaths | Baseline | Number of deaths will be determined by number of patient deaths due to any cause |
| Change in effective diuresis | Baseline, up to 90 Days | Diuresis will be measured from a urine sample and calculated by total diuresis in liters/admission weight in kilograms |
| Change in diuretic dosing | Baseline, up to 90 Days | Diuretic dosing will be measured in mg |
| Change in Lung Congestion | Baseline, up to 90 Days | Lung congestion will be measured using a lung ultrasound and measured as a percentage |
Countries
United States
Contacts
CONTACTAndy Dang
PRINCIPAL_INVESTIGATORJared Bird, MD
Mayo Clinic
Outcome results
None listed