Healthy Participants, Knee Arthroplasty, Total
Conditions
Brief summary
This project evaluates a new weight-bearing CT method to later improve early detection of implant migration after knee arthroplasty. This method aims to allow patients to apply a controlled load during CT scanning, simulating standing conditions with real-time feedback. The study has two phases. First, in healthy volunteers, biomechanical loading during prone simulated weight-bearing will be compared with a standard standing squat to validate the method. Second, in arthroplasty patients, standard radiographs will be compared with loaded and unloaded WBCT scans. Patients will not deviate from the standard plan of care. The CT images are additions to the standard RX images and are not intended for diagnostic purposes to the patient. The aim is to determine whether this method opens the door for more accurate and earlier detection of implant migration than current clinical imaging in the future, potentially improving long-term outcomes after knee arthroplasty.
Interventions
DIAGNOSTIC_TESTStatic supine weight bearing CT
Static supine weight bearing CT in addition to standard care RX
Sponsors
Vrije Universiteit Brussel
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Healthy participants * Patients with TKA
Exclusion criteria
* neurological conditions * acute trauma
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Validation of static supine weight bearing against standing weight bearing using kinematic parameters | 1 year | Comparison of lower-limb and trunk joint kinematics between static supine weight-bearing and standing weight-bearing conditions in healthy subjects using marker-based motion capture. Unit of Measure: Degrees (°) |
| Validation of static supine weight bearing against standing weight bearing using kinetic parameters | 1 Year | Comparison of ground reaction forces and joint moments between static supine weight-bearing and standing weight-bearing conditions in healthy subjects using force plate measurements. Unit of Measure: Newtons (N) and Newton-meters (Nm) |
| Validation of static supine weight bearing against standing weight bearing using muscle activation | 1 year | Comparison of lower-limb muscle activation patterns between static supine weight-bearing and standing weight-bearing conditions in healthy subjects using surface electromyography. Unit of Measure: Percentage of maximum voluntary contraction (%MVC) |
Contacts
CONTACTNicolas Van Vlasselaer, Master
Outcome results
None listed