Obesity, Periodontal Diseases
Conditions
Brief summary
Obesity and periodontitis are among the most common chronic disorders affecting the world population, while Prolactin (PRL) is a neuroendocrine hormone that within the physiological range stimulates bone formation while mild to marked increase in its level induces bone resorption and inhibits bone formation. Aim of the study: study aims to investigate prolactin (PRL) levels in gingival crevicular fluid (GCF) in obese (O) patients with and without stage II and III periodontitis (P). Further, to evaluate the effect of non-surgical periodontal therapy on these levels compared to controls.
Interventions
OTHERObese patients with stage II and III periodontitis and non surgical peridontal therapy
Patients had BMI of more than 29.9 kg/m2. charaterized by Stage II periodontitis with clinical attachment loss of 3-4 mm, radiographic bone loss confined to the coronal third, and no history of tooth loss due to infection and Stage III signifies severe destruction with attachment loss of more th toan or equal 5 mm, bone loss extending into the middle or apical third of the root, and potential tooth loss of up to four teeth. Patients will undergo full mouth scaling and root planning for two sessions
OTHERobese patients with healthy periodontium with no intervention
Patients had BMI of more than 29.9 kg/m2 but with healthy peridontium
Sponsors
Alexandria University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
25 Years to 55 Years
Healthy volunteers
No
Inclusion criteria
* Body mass index (more than 29.9 kg/m2). * stage II and III periodontitis
Exclusion criteria
* Pregnancy or lactation. * Any known systemic disease other than obesity * Previous periodontal treatment (surgical or non-surgical) in last 6 months; * Antibiotics in the past 3 months. * Smoking
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| change in clinical attachment level | Baseline and 3 months | Clinical attachment level (CAL) using a Williams probe (which manufactured in Europe from AISI 304 Stainless steel) from a fixed reference point on the crown to the base of the pocket. |
| change in GCF levels of prolactin hormone | Baseline and 3 months | Gingival crevicular fluid sample will be obtained from the buccal aspects of two interproximal sites in teeth that will have the highest signs of inflammation and attachment loss |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| change in Probing depth | Baseline and 3 months | measured from the margin of the gingiva to the base of the pocket until slight resistance is encountered using a Williams probe (which manufactured in Europe from AISI 304 Stainless steel). |
| change in gingival index | Baseline and 3 months | Gingival Index evaluates the severity of gingivitis by scoring the color, consistency, and bleeding tendency of the soft tissues on a scale of 0 to 3, where a score of 2 indicates bleeding upon probing and a 3 signifies spontaneous bleeding |
| change in plaque index | Baseline and 3 months | Plaque Index focuses exclusively on the thickness of the microbial biofilm at the gingival margin, ranging from a score of 1, where plaque is only detectable by running a probe across the surface, to a score of 3, characterized by an abundance of visible soft matter. |
Countries
Egypt
Outcome results
None listed