Salivary Dysfunction, Smell Dysfunction, Taste Dysfunction, Trigeminal Dysfunction
Conditions
Keywords
Smell, Taste, Trigeminus, Salivation
Brief summary
Taste, smell, trigeminal and salivary function is impacted in post-COVID-19 patients
Interventions
OTHERSmell training
Smell training
Sponsors
University of Oslo
Study design
Allocation
NA
Intervention model
SEQUENTIAL
Primary purpose
SCREENING
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
-COVID-19 diagnosis
Exclusion criteria
-Not COVID-19 diagnosis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Smell | two years | Olfactory (smell) function will be evaluated using the Twelve felt-tip Sniffin' Sticks test (Burghart Messtechnik GmbH, Holm, Germany). Participants are categorized into anosmic (score 0-6, no smell), hyposmic (score 7-10, reduced smell), and normosmic (score 11-12, normal smell), according to normative classification. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Dysesthesia | 2 years | Dysesthesia (oral burning sensation) iss categorized as either no dysesthesia (score 0), or dysesthesia (score 1). Participants report how often they experienced dysesthesia (constantly, daily, sometimes, periodically, during meals, in between meals), asked to describe where in the mouth they experienced dysesthesia (whole tongue, anterior tongue, lips, palate, buccal mucosa, other), and identify food items that enhanced the dysesthesia (spicy, sweet, sour, salty, bitter). |
| Dry mouth | 2 years | Xerostomia (oral dryness) iss categorized according to participants' self-reported perception as either no dry mouth (score 0), or dry mouth (score 1). Participants are asked whether the symptoms of xerostomia started before or after COVID-19 infection and are asked open-ended questions where they could describe their experience of oral dryness. Finally, they are asked to report whether there are food items that they had to refrain from eating because of parosmia, dysgeusia, dysesthesia or xerostomia. |
| Taste | 2 years | Gustatory (taste) function is assessed using Taste Strips impregnated with solutions of four different taste qualities (sweet, sour, salty, and bitter) in four different concentrations (Burghart Messtechnik GmbH, Holm, Germany). Participants are classified into ageusic (score 0, no taste), hypogeusic (score 1-8, reduced taste) and normogeusic (score 9-16, normal taste) using a normative classification. Participants are considered to have a specific ageusia if they are unable to detect all four different concentrations of a particular tastant. |
Countries
Norway
Contacts
PRINCIPAL_INVESTIGATORPer Ole Iversen, PhD
Per Ole Iversen
Outcome results
None listed