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Hemorrhage Stroke Decision Making Model Based Deep Learning (BrainHemoAI System)

Construction of an Integrated Intelligent Model for Spontaneous Intracerebral Hemorrhage Based on Deep Learning

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07570680
Enrollment
7100
Registered
2026-05-06
Start date
2022-09-01
Completion date
2026-12-30
Last updated
2026-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemorrhage Stroke

Brief summary

Although hemorrhagic stroke also has the characteristics of high mortality and disability rates, and constitutes a major public health problem worldwide, there is a relative lack of in-depth research teams for hemorrhagic stroke in China. The current preoperative imaging evaluation of spontaneous cerebral hemorrhage is still limited to the traditional Tada formula, and there are subjective differences in diagnosis among different doctors, making it difficult to achieve homogenization in clinical decision-making. Hemorrhagic stroke is a common and frequently occurring disease in Jiangxi Province. Therefore, establishing a new diagnosis and treatment system focused on hemorrhagic stroke can not only fill the research gap in this field in China, improve the accuracy and homogeneity of hemorrhagic stroke diagnosis and treatment, but also promote related research progress to reduce the mortality and disability rates of this disease and improve the clinical prognosis of patients.

Detailed description

Hemorrhagic stroke is a serious cerebrovascular disease, accounting for about 20% of all strokes. It refers to cerebral hemorrhage and subarachnoid hemorrhage caused by intracranial vascular diseases such as intracranial aneurysms, cerebral and spinal vascular malformations and moyamoya disease under the effect of blood flow. It has the characteristics of high incidence rate, high disability rate and high mortality rate, and has caused huge economic burden to patients, families and society. Hemorrhagic stroke is one of the high-risk diseases in Jiangxi Province, and has become a major public health challenge and a key social issue that urgently needs to be addressed. On the one hand, the diagnosis and treatment of hemorrhagic stroke have a certain degree of complexity, involving multiple disciplines, especially neurology and endocrinology, which have established multiple diagnostic, evaluation, treatment, and rehabilitation systems. Different systems have different focuses, but limited by the level of understanding of the disease, there have been only basic treatment principles for decades, and there has been no breakthrough in specific treatment plans. On the other hand, with the development of the economy and the improvement of living standards, clinical physicians and patients not only focus on the survival rate after hemorrhagic stroke, but also pay more attention to neurological function recovery and long-term quality of life. Due to the limitations of detection technology in the past, it was difficult to accurately describe diseases and truly develop individualized diagnosis and treatment plans, resulting in significant differences in patient prognosis. How to leverage advances in diagnosis and treatment technology to ultimately achieve precision, individualization, and homogenization in the diagnosis and treatment of hemorrhagic stroke is a key focus for the future. Although hemorrhagic stroke also has the characteristics of high mortality and disability rates, and constitutes a major public health problem worldwide, there is a relative lack of in-depth research teams for hemorrhagic stroke in China. The current preoperative imaging evaluation of spontaneous cerebral hemorrhage is still limited to the traditional Tada formula, and there are subjective differences in diagnosis among different doctors, making it difficult to achieve homogenization in clinical decision-making. Hemorrhagic stroke is a common and frequently occurring disease in Jiangxi Province. Therefore, establishing a new diagnosis and treatment system focused on hemorrhagic stroke can not only fill the research gap in this field in China, improve the accuracy and homogeneity of hemorrhagic stroke diagnosis and treatment, but also promote related research progress to reduce the mortality and disability rates of this disease and improve the clinical prognosis of patients.

Interventions

DIAGNOSTIC_TESTLarge language model

Automatical diagnosis, treatment decision-making, and risk prediction after spontaneous intracerebral hemorrhage via a trained deep learning larger language model.

Sponsors

Second Affiliated Hospital of Nanchang University
Lead SponsorOTHER
First Affiliated Hospital of Gannan Medical University
CollaboratorOTHER
Zhejiang University
CollaboratorOTHER
Ganzhou City People's Hospital
CollaboratorOTHER
The First People's Hospital of Xiushui
CollaboratorOTHER
Jiujiang No.1 People's Hospital
CollaboratorOTHER
Renmin Hospital of Wuhan University
CollaboratorOTHER
First Affiliated Hospital of Zhejiang University
CollaboratorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
8 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

1. Age \>= 8 years old; 2. Patients diagnosed with spontaneous hemorrhagic stroke based on medical history and auxiliary examinations; 3. Received non-contrast computed tomography (NCCT) in the outpatient or emergency department; 4. Treated in accordance with standard clinical guidelines during hospitalization; 5. Have complete clinical data.

Exclusion criteria

1. Had undergone surgical treatment in another hospital before admission; 2. Was in a state of shock upon admission; 3. Had severe heart, liver, or kidney dysfunction or other life-threatening systemic diseases; 4. Died during hospitalization; 5. Had an expected lifespan of less than six months or was unable to complete the study follow-up for other reasons.

Design outcomes

Primary

MeasureTime frameDescription
Area Under Curve90-day and 180-day90-day and 180-day mRS score, survival status, functional independence (Barthel index).

Secondary

MeasureTime frameDescription
Sensitivity ,Specificity,True Positive Rate,False Positive RateBaseline (admission), 24 hours postoperatively, 3 days postoperatively, 7 days postoperatively, discharge, 90-day follow-up, 180-day follow-upIncluding hospital stay, ICU stay, hospitalization costs, rebleeding, delayed cerebral ischemia, intracranial infection, and hydrocephalus flow surgery needs

Countries

China

Contacts

CONTACTXingen Zhu, Prof
zxg2008vip@163.com13803546020
CONTACTPing Hu, PhD;MD
hp666edu@163.com13207109734

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: May 7, 2026