Atrophic Scar
Conditions
Brief summary
Lay Summary (Simple Explanation) Atrophic scars are depressed scars that form when the skin does not heal properly, commonly seen after acne or injuries. These scars can affect appearance and confidence, and current treatments may not always give satisfactory results. This study aims to evaluate a new treatment using exosomes, which are tiny particles naturally released by cells that help in skin repair and regeneration. Researchers will compare the effect of injecting exosomes directly into scars versus injecting a simple saltwater solution (saline), which serves as a control. Participants will be randomly assigned to receive either exosome injections or saline injections. Neither the patient nor the evaluator may know which treatment is given, to ensure fair comparison. The goal is to determine whether exosomes can safely and effectively improve the appearance and texture of atrophic scars.
Interventions
OTHERIntralesional exosomes
exosomes are injected within the substance of the scar.
OTHERIntralesional Saline
all patients will receive both, exosomes and saline, each injected into one scar.
Sponsors
Zagazig University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Age \>18 years * Either gender * Scars of any duration * Multiple scars at one side or both sides of the face. * Patients are willing to sign written informed consent statements before beginning treatment.
Exclusion criteria
* Pregnant females. * Patients with one scar. * Hypersensitivity to any of the used treatments. * Patient with infection at the site of the scar. * Patients with unrealistic expectations. * Patient refusing to sign on the consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| modified Manchester Scar Scale | 3 months after 4 biweekly sessions | Scar appearance was assessed using the Modified Manchester Scar Scale. The Modified Manchester Scar Scale ranges from 4 to 24, with lower scores indicating better scar appearance and higher scores indicating worse scar appearance |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Scar thickness measurement in millimetres by Ultrasound examination | 3 months after 4 biweekly sessions | Scar characteristics, including scar thickness and echogenicity, will be assessed using high-frequency ultrasound examination. Scar thickness will be measured in millimeters, and changes from baseline to follow-up will be summarized. Higher scar thickness values indicate greater scar tissue thickness |
Countries
Egypt
Contacts
CONTACTmona Elradi
Outcome results
None listed