Successive Doses of GnRH Agonist Versus Single Dose of GnRH Agonist to Trigger Ovulation in Hyper-responders

Successive Doses of GnRH Agonist Versus Single Dose of GnRH Agonist to Trigger Ovulation in Hyper-responders Undergoing IVF Cycle : A Randomized Controlled Study.

Status

Not yet recruiting

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07569315

Enrollment

190

Registered

2026-05-06

Start date

2026-06-01

Completion date

2028-04-01

Last updated

2026-05-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility

Keywords

Infertility, GnRH agonist trigger, IVF-ET, Hyper-responders, PCOS

Brief summary

The aim of this randomized controlled study is to compare the efficacy of three successive doses of a GnRH agonist ( administered 36 , 24 and 12 hours before oocyte retrieval ) with a single dose of a GnRH agonist ( administered 36 hours before oocyte retrieval ) in triggering ovulation in hyper-responders

Interventions

DRUGSuccessive doses GnRH agonist

GnRH agonist ( Triptorelin ) ( 0.2 mg / S.C ) is administered 36 hours before ovum pickup. Two additional doses of triptorelin ( 0.1 mg / S.C ) are administered subcutaneously 12 and 24 hours after the first dose of GnRH agonist.

DRUGSingle dose GnRH agonist

GnRH agonist ( Triptorelin ) ( 0.2 mg / S.C ) is administered 36 hours before ovum pickup.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 40 Years

Healthy volunteers

Inclusion criteria

* GnRH antagonist IVF cycle * Hyper-responders to induction of ovulation

Exclusion criteria

* Hypogonadotrophic hypogonadism * Endometriosis * History of recurrent abortion

Design outcomes

Primary

Measure	Time frame	Description
Metaphase-II oocytes rate	Ten to fifteen days after starting ovarian stimulation	Number of MII oocyte/ number of cumulus oocyte complex

Secondary

Measure	Time frame	Description
Clinical pregnancy rate	Five weeks after embryo transfer	Presence of intrauterine gestational sac detected by transvaginal ultrasound
Ongoing pregnancy Rate	Eighteen weeks after embryo transfer	Pregnancies continued beyond 20 weeks gestation

Countries

Egypt

Contacts

CONTACTUsama M. Fouda, Prof.

umfrfouda@yahoo.com+201095401375

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: May 12, 2026