Infertility (IVF Patients)
Conditions
Keywords
Infertility, IVF-ET, Normo-responders, GnRH agonist, HCG
Brief summary
The aim of this randomized controlled study is to compare the efficacy of a modified dual trigger protocol \[a single bolos of HCG combined with two successive doses of a GnRH agonist \] with HCG \[a single bolos administered 36 hours before oocyte retrieval \] in triggering ovulation in normo-responders undergoing ovarian stimulation using the antagonist protocol.
Interventions
DRUGModified dual trigger
HCG (10000 IU /IM) and triptorelin (0.2 mg/S.C) are administered 36 hours before ovum pickup . Moreover, 0.1mg of triptorelin is administered 24 h prior to ovum pick-up.
DRUGHCG
HCG (10000 IU/IM ) is administered 36 hours before ovum pickup.
Sponsors
Bedaya Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* GnRH antagonist IVF cycle * Normo-responders to induction of ovulation
Exclusion criteria
* Hypogonadotrophic hypogonadism * Endometriosis * History of recurrent abortion
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Metaphase-II oocytes rate | Ten to fifteen days after starting ovarian stimulation | Number of MII oocyte/ number of cumulus oocyte complex |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Clinical pregnancy rate | Five weeks after embryo transfer | Presence of intrauterine gestational sac detected by transvaginal ultrasound |
| Ongoing pregnancy Rate | Eighteen weeks after embryo transfer | Pregnancies continued beyond 20 weeks gestation |
Countries
Egypt
Contacts
CONTACTUsama M Fouda, Prof
Outcome results
None listed