Infertility
Conditions
Keywords
Infertility, Poor responders, IVF-ET, HCG, GnRH agonist, Double trigger
Brief summary
The aim of this randomized controlled study is to compare the efficacy of double trigger protocol \[ the co-administration of GnRH agonist with HCG ( 38 - 39 and 35 - 36 h prior to ovum pick-up, respectively \] with HCG in triggering ovulation in patients with expected poor response to ovarian stimulation
Interventions
DRUGDouble trigger
Triptorelin (0.2 mg/S.C ) and HCG (10000 IU/I.M) are administered 38 to 39 h and 35 to 36 h prior to ovum pick-up., respectively.
DRUGHCG trigger
HCG (10000 IU/I.M) is administered 35 to 36 h prior to ovum pick-up.
Sponsors
Bedaya Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* POSEIDON group 3 and 4 * GnRH antagonist IVF cycle
Exclusion criteria
* Hypogonadotrophic hypogonadism * Endometriosis * History of recurrent abortion
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Metaphase-II oocytes rate | Ten to fifteen days after starting ovarian stimulation | Number of MII oocyte/ number of cumulus oocyte complex |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Clinical pregnancy rate | Five weeks after embryo transfer | Presence of intrauterine gestational sac detected by transvaginal ultrasound |
| Ongoing pregnancy Rate | Eighteen weeks after embryo transfer | Pregnancies continued beyond 20 weeks gestation |
Countries
Egypt
Contacts
CONTACTUsama M Fouda, Prof.
Outcome results
None listed