Healthy Adult Participants
Conditions
Brief summary
Protein supplementation is said to be one of the cost-efficient and practical strategies to meet protein needs for growth and exercise, and can help maximize muscle gain from resistance exercise. It facilitates faster recovery from stress-induced tissue damage and enhances performance output. Protein sources derived from animal products are generally recognized as the highest quality protein. However, altering the protein composition of a protein source can improve the protein quality. The yeast protein supplement the investigators will use in this study has a similar amino acid composition to whey protein, which is derived from an animal product, but it is produced more sustainably. The study aims to compare the effects of yeast and whey protein on muscle mass over 16 weeks.
Detailed description
This is a double-blinded randomized clinical trial of a 16-week nutrition intervention with yeast and whey protein in 72 people (36 per group; 18 male and 18 female) between the ages of 18 and 35, recruited from the University of Alberta campus, Edmonton, Canada. Consenting participants will be randomly assigned to one of two groups: whey protein or yeast protein by the study coordinator, who will not collect study outcome measurements or analyze the data. The goal of the trial is to determine if consumption of 40 g per day of yeast protein produces similar effects to 40 g supplementation with whey protein. It is anticipated that daily yeast protein consumption will show similar gains in muscle mass and improvement in immune function, increased diversity in gut microbiota, and amino acid-derived metabolites compared to whey protein.
Interventions
DIETARY_SUPPLEMENTYeast Protein
60g of protein supplement (40g of protein). Oral administration, 30g during exercise and anytime after exercise, or 30g in the morning and evening if no exercise is performed for a period of 16 weeks.
Lower and upper body resistance training exercises 3 times a week for 16 weeks
DIETARY_SUPPLEMENTWhey Protein
60g of protein supplement (40g of protein). Oral administration, 30g during exercise and anytime after exercise, or 30g in the morning and evening if no exercise is performed for a period of 16 weeks.
Sponsors
University of Alberta
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Participants must have the ability to read, understand, and sign an informed consent and must be willing to comply with study treatment and follow-up. * Prior resistance training experience (defined as performing resistance exercises \>1/week for the past 3 months or longer) to enable them to reach a large training stimulus relatively quickly and to avoid the longer phase of neuromuscular adaptations * ≥18 years and \<35 years of age
Exclusion criteria
* Diabetes, musculoskeletal disease, cancer, Crohn's disease, or any other acute or chronic condition that interferes (or the medication prescribed for those conditions) with muscle anabolism. * Diagnosed with or being treated for heart disease, stroke, high blood pressure 130/80 mmHg or higher * Pain/discomfort/pressure in the chest during activities of daily living or physical activity * Pregnant or not on adequate contraception. * A known hypersensitivity/allergy to ingredients in the supplements. * Inflammatory bowel diseases * Enrolment in any other clinical protocol or investigational study that may interfere with study procedures * Taking antibiotics
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in muscle mass | 16 weeks | The primary outcome of the study is the change in muscle mass. It is hypothesized that participants consuming yeast protein will show an increase in appendicular lean mass similar to that observed with whey protein. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in muscle function, inflammatory biomarkers, oxidative stress markers, gut microbiota and metabolites | 16 weeks | The secondary outcomes of the study include changes in muscle function, which will be assessed through one repetition maximum (1RM) testing for both the bench press and leg press. Additionally, the investigators will evaluate inflammatory biomarkers, specifically plasma cytokines, as well as oxidative stress markers such as glutathione, total antioxidant capacity, and protein carbonyl levels. The study will also investigate gut microbiota and metabolites. The investigators hypothesize that the secondary outcomes will show similar effects in participants taking yeast protein compared to those taking whey protein. |
Countries
Canada
Contacts
CONTACTJianping Wu, PhD
Outcome results
None listed