Nutritional Intervention Implication in Enhanced Recovery After Surgery for Whipple Procedure

Implication of Nutritional Intervention in Enhanced Recovery After Surgery for Whipple Procedure/Pylorus Preserving Pancreatoduodenectomy

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07560540

Acronym

{ERAS}

Enrollment

Registered

2026-05-01

Start date

2025-12-01

Completion date

2026-12-01

Last updated

2026-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ampulla of Vater Adenocarcinoma, Billiary Track Cancer, Pancreatic Cancer

Brief summary

The objective of this research is to assess the impact of personalized nutritional intervention on postoperative complications and length of stay in Whipple's patients via assessing the parameters related to body composition, nutritional status, weight maintenance, biochemical profile (LFTs, RFTs, CBC, CRP, serum electrolytes, coagulation profile and HbA1c) and muscle preservation postoperatively. Moreover, enhanced recovery after surgery (ERAS) guidelines in Whipple's patients will also be monitored. Exactly 20 patients undergoing Whipple's Procedure/PPPD in 1 year will be recruited for the study. Medical nutrition therapy will include energy intake of 25- 30 Kcal/kg body weight and protein 1.2-1.5g/kg body weight. Enteral nutrition and parenteral nutrition will be given accordingly. After discharge, patients receiving chemotherapy and patients not receiving chemotherapy will be nutritionally intervened accordingly. Follow-ups will be done in the 2nd week, 3rd month and 6th month after surgery. Data will be analyzed using SPSS version 27. To assess the significant difference among study groups t-test, repeated measure analysis of variance (ANOVA) and regression model will be applied. The level of significance will be kept at 5%. t-test for treatment groups.

Interventions

OTHERNutrition Intervention

Personalized Nutrition Intervention (Medical nutrition therapy will include energy intake of 25- 30 Kcal/kg body weight and protein 1.2-1.5g/kg body weight using enteral nutrition)

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Malignancy of; * Distal common bile duct * Pancreatic head * Periampullary * Duodenal * Patients scheduled for elective Whipple's procedure (laparoscopic and open) * Age 18 and above

Exclusion criteria

* Patients undergoing Whipple's procedure for reasons other than malignancy * Patients undergoing emergency procedures * Patients with significant preoperative complications prohibiting oral intake * Age below 18

Design outcomes

Primary

Measure	Time frame	Description
Evidence-based data for ERAS focusing on nutritional recommendations in Whipple's Procedure/PPPD will be generated for the Pakistani population.	2 years	The research and evidence-based data for ERAS focusing on nutritional recommendations in Whipple's Procedure/PPPD will be generated for the Pakistani population. The impact of the nutritional intervention with the available resources will be measured by Body Composition Analysis, Patient Generated Subjective Global Assessment and Biochemical Profiling.

Countries

Pakistan

Contacts

CONTACTJaveriya Afzal, MPhil Food and Nutrition

javeriyaafzal23@gmail.com00923244090078

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: May 2, 2026