Liver Cirrhosis, Portal Vein Thrombosis
Conditions
Keywords
Portal vein thrombosis, liver cirrhosis, D-dimer
Brief summary
Portal vein thrombosis (PVT) is a common complication in patients with liver cirrhosis and is associated with increased morbidity due to worsening portal hypertension and hepatic decompensation. The clinical presentation and radiological patterns of PVT vary widely, and the factors predicting its development remain incompletely understood. This observational study will include adult patients (≥18 years) with established liver cirrhosis who are admitted to the Department of Gastroenterology and Tropical Medicine, Al-Rajhi Liver Hospital, Assiut University. Eligible participants will undergo routine screening for PVT using Doppler ultrasonography, with confirmation by contrast-enhanced computed tomography when indicated. The study aims to evaluate the clinical characteristics, laboratory parameters, and radiological features of PVT. Cases of PVT will be classified according to extent (partial or complete) and anatomical location (main portal vein, right branch, left branch, or combined involvement). Clinical and laboratory data will be analyzed to identify potential predictors associated with the development and severity of PVT. The findings of this study are expected to improve understanding of the risk factors and radiological patterns of PVT in cirrhotic patients, contributing to better risk stratification and clinical management.
Interventions
DIAGNOSTIC_TESTAbdominal US, Doppler US and abdominal multi-slice computed tomography (MSCT) with contrast was performed
to assess portal circulation, portosystemic collaterals, the presence of PVT, ascites and HCC.
Sponsors
Elham Ahmed Hassan
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult patients with liver cirrhosis
Exclusion criteria
* Patients with non-hepatic hemostatic disorders, active bacterial sepsis, renal dysfunction, peripheral or hepatic venous thrombosis, recent splenectomy, liver transplantation, antiplatelet or anticoagulant therapy or contraceptive pills were excluded.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of Portal Vein Thrombosis (PVT) | At baseline (during study enrollment period) | Proportion of cirrhotic patients diagnosed with portal vein thrombosis based on Doppler ultrasonography with confirmation by contrast-enhanced CT when indicated. |
| Predictors of Portal Vein Thrombosis | Baseline assessment | Identification of clinical, laboratory, and radiological factors associated with the presence of PVT in cirrhotic patients |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Radiological Pattern of PVT | At time of PVT diagnosis | Distribution of portal vein thrombosis according to: Extent (partial vs complete) Anatomical location (main portal vein, right branch, left branch, or combined involvement) |
| Association Between PVT Type and Clinical Parameters | At time of diagnosis | Correlation between type of PVT (partial vs complete) and clinical/laboratory characteristics of patients. |
Countries
Egypt
Outcome results
None listed