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Efficacy of Selective COX-2 Inhibitors in Relieving Orthodontic Pain

Efficacy of Selective COX-2 Inhibitors in Relieving Orthodontic Pain ;a Randomized Controlled Trial

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07559682
Acronym
EOSCOX2
Enrollment
150
Registered
2026-04-30
Start date
2025-05-08
Completion date
2026-04-30
Last updated
2026-04-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Orthodontic Pain (D013850)

Brief summary

The purpose of this study is to compare the efficacy of selective COX-2 inhibitors{ etoricoxib vs celecoxib )in relieving orthodontic pain , after initial bonding and arch wire insertion.

Interventions

DRUGCelecoxib

Group A will be given Celecoxib 50mg once a day.

DRUGEtoricoxib (Treatment Group)

Group B will be given Etoricoxib 60mg once a day.

Sponsors

Sharif Medical Research Center
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Caregiver)

Eligibility

Sex/Gender
ALL
Age
13 Years to 30 Years
Healthy volunteers
No

Inclusion criteria

1. Age 13 to 30 years 2. Fully erupted permanent dentition excluding third molars 3. Mild crowding (0 -4mm)

Exclusion criteria

1. Active periodontitis 2. Deep cavities or large restorations 3. Previous dental extraction in less than 4 weeks before bonding 4. History of steroid use within last 6 weeks

Design outcomes

Primary

MeasureTime frameDescription
Pain intensity1 yearPain scores will be measured using a 10cm Visual Analogue Scale (VAS) , The Scale consists of a horizontal line anchored by two verbal descriptions where 0 represented '' No Pain '' and 10 represented ''Maximum Pain''. The Score is determined by measuring the distance from left end of the scale to the mark made by the participant.

Countries

Pakistan

Contacts

STUDY_CHAIRFaiza Malik, BDS, FCPS

Essentia Health

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: May 1, 2026