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Effects of Hot Baths Prior or After a Damaging Protocol on Muscle Function and HSP70 Expression

Effects of Hot Baths Prior or After a Damaging Protocol on Muscle Function and HSP70 Expression

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07559344
Acronym
Prehotemp
Enrollment
96
Registered
2026-04-30
Start date
2026-02-16
Completion date
2027-02-01
Last updated
2026-04-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Recovery, Mechanical Stress, Heat Stress, HSP70, Cumulative Response, Hot-water Immersion

Keywords

Recovery, mechanical stress, heat stress, HSP70, cumulative response, hot-water immersion

Brief summary

Muscle lengthening contractions lead to physiological responses such as strength loss, soreness, immune cell infiltration, and CK production, along with elevated heat shock proteins (HSPs), which protect and regenerate cells. Passive heating before or after exercise can aid in recovery by restoring strength and reducing soreness, requiring a core temperature of over 38.5°C for 20 minutes to be effective. Studies show that combined mechanical and thermal stress induces a cumulative HSP response, enhancing cellular protection. Thermal stress alone peaks at 16- 24 hours, whereas mechanical stress shows a biphasic response, with peaks at 3-6 hours and around 39 hours. Thus, combining heat with exercise could optimize HSP production, improving recovery by increasing and accelerating the HSP response. However, more research is needed to determine the best timing for thermal stress in human applications, especially in sports and therapy contexts. This study aimed to compare the effects of hot-water immersion administered before versus after muscle-lengthening exercise on muscle function and HSP70 expression in healthy young athletes.

Interventions

Immersion lasted 40 minutes with the goal of reaching a core temperature of 38.5°C in the heat-stress groups

OTHERNIRS

NIRS

isokinetic dynamometer

pressure algometer

OTHERHokanson armband

Hokanson armband

Sponsors

Centre Hospitalier Universitaire, Amiens
Lead SponsorOTHER
CH CORBIE
CollaboratorUNKNOWN

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Subject)

Eligibility

Sex/Gender
MALE
Age
19 Years to 25 Years
Healthy volunteers
No

Inclusion criteria

* Sex: Healthy, athletic men practicing track and field (10 to 12 hours/week) * Age: 19 to 25 years old * Social security coverage * Signed informed consent

Exclusion criteria

* Age over 26 years * Low level of physical activity (less than 8 hours per week) * Recent sprain (type 1, 2, or 3) or ligament rupture in the lower limb (within the last 8 months) * Exposure to an altitude of 2500m within 15 days prior to the protocol * Presence of arterial hypotension: * Systolic blood pressure below 90 mmHg * Diastolic blood pressure below 60 mmHg * A drop in systolic blood pressure greater than 20 mmHg upon moving from a lying to a standing position. * A drop in diastolic blood pressure greater than 10 mmHg upon moving from a lying to a standing position. * Presence of dizziness, lightheadedness, or blurred vision upon moving from a lying to a standing position. * Participant under guardianship/conservatorship or deprived of liberty.

Design outcomes

Primary

MeasureTime frameDescription
HSP 70 concentration1 yearHSP 70 concentration in third groups

Secondary

MeasureTime frame
gastro-intestinal temperature1 year
muscle temperature1 year

Countries

France

Contacts

CONTACTYannis Hamidou, MD
Hamidou.yannis@chu-amiens.fr33+3 22 66 82 48

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: May 1, 2026