Endometrium Cancer, Gynecologic Cancer
Conditions
Keywords
Molecular classification, Endometrial cancer treatment, Endometrial cancer epidemiology, Endometrial cancer surgical procedures, Minimally invasive surgery, Gynecologic Oncology
Brief summary
The aim of this study is to lay the bases for an ambitious project that reports and records all the epidemiological-clinical information of the cases of endometrial carcinoma diagnosed and treated in the reference oncology centers involved on the national territory, to create a process of analysis of the data
Detailed description
Endometrial cancer represents the most common gynecological cancer in industrialized countries and the fourth most common neoplasm after breast, lung and colorectal cancer. Unlike other neoplasms, its incidence and mortality are continuously increasing. In this context, the National Health System requires an optimization of the diagnosis and treatment strategies of this carcinoma. This aspect leads a continuous effort to improve to properly manage the impact that this disease has on female health in Italy. Throughout the world, there are national, supranational models and registers aimed at establishing and managing over time an archive of all newly diagnosed cancer cases, ensuring that data recording takes place in a rigorous, continuous and systematic manner. An excellent example of this is the SEER of the National Cancer Institute of America, which has the task of recording and monitoring the epidemiological-clinical data of various carcinomas, to monitor the clinical progress and management of therapeutic programs of neoplastic pathologies. This program represents the epidemiological and statistical basis of important scientific evidence, both prospective and retrospective, aimed at reporting and demonstrating the effectiveness of preventive, diagnostic and therapeutic approaches in the various oncological pathologies examined. On these premises, the aim of this study is to lay the bases for an ambitious project that reports and records all the epidemiological-clinical information of the cases of endometrial carcinoma diagnosed and treated in the reference oncology centers involved on the national territory, to create a process of analysis of the data
Interventions
None listed
Sponsors
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* diagnosis of endometrial cancer (stage I-IV, G1-3, and special histotypes) * age \> 18 years * American Society of Anesthesiologists classification (ASA score) 1-3 * patients undergoing staging, cytoreduction or diagnostic surgery with acquisition of histological examination on which IHC and/or NGS studies have been performed for the molecular profile of the carcinoma * Signed informed consent
Exclusion criteria
* patients with missing information * patients not treated in the participating centers for which only partial and fragmented information will be available * molecular profile not known and\\or not recoverable and retrospectively analysable
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Disease Free Survival | Baseline. | To evaluate the impact of the immuno-molecular and clinical profile of endometrial cancer on the outcomes of DFS (Disease-Free Survival). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Overall Survival | Baseline. | To evaluate the impact of the immuno-molecular and clinical profile of endometrial cancer on the outcomes of OS (overall survival). |
Countries
Italy
Contacts
CONTACTFrancesco Fanfani, MD
PRINCIPAL_INVESTIGATORFrancesco Fanfani
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Outcome results
None listed