Brain Tumor, Pediatric
Conditions
Keywords
Brain Tumor, Pediatric, Pediatric Brain Tumor, Cognitive Intervention, Intervention, Oncology, Cancer
Brief summary
The goal of this study is to learn if an online computerized training program improves processing speed, attention, and working memory in children with a primary brain tumor during and after active cancer treatment. The main questions it aims to answer are: 1. Is the cognitive intervention feasible to administer to children with brain tumors during and after cancer treatment?, 2. Is the cognitive intervention acceptable to children and caregivers?, and 3. Does the cognitive intervention improve neuropsychological functioning? There is no comparison group for this study. Participants will: 1. Complete an online computerized cognitive training program for approximately 15 minutes per day, 5 days a week, for 8 weeks; 2. Have weekly check-ins with the cognitive coach, 3. Complete a survey at the end of the cognitive training program, and 4. Complete pre- and post- neuropsychological testing.
Interventions
BEHAVIORALOnline computerized cognitive training intervention focused on processing speed.
This online cognitive training program aims to improve processing speed through computerized cognitive exercises. Participants will complete approximately 15 minutes of training, 5 days per week for 8 weeks. Weekly check-ins with a cognitive coach will assist with engagement and problem solve any barriers.
Sponsors
Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
5 Years to 25 Years
Healthy volunteers
No
Inclusion criteria
1. Diagnosis of a primary brain tumor, 2. Children and young adults 5 to 25 years of age at the time of enrollment, 3. Within five years of initial brain tumor diagnosis, 4. Receiving care through the Johns Hopkins neuro-oncology program.
Exclusion criteria
1. Significant visual, hearing, motor, or cognitive impairment that precludes participation in computerized cognitive training program; 2. Acute medical status (e.g., significant risk for mortality within 3-months of diagnosis).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Feasibility - Enrollment | Up to 5 years after diagnosis. | Study enrollment rate. |
| Feasibility - Participant Retention | 8 weeks | Number of participants who complete the computerized brain training program. |
| Feasibility - Intervention Adherence | Through study completion, an average of 8 weeks. | Number of levels completed in the cognitive training program. Qualitative feedback regarding barriers and facilitators to engagement will also we collected to provide descriptive context. |
| Feasibility - Total Intervention Time | 8 weeks | Total time spent completing the cognitive training program exercises. |
| Acceptability | At the end of the 8-week intervention. | Parent and self-reported acceptability measured using a Likert-scale questionnaire administered at the end of the intervention. Mean total score will be reported. Qualitative feedback regarding participant experience will also be collected to provide descriptive context. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cognitive Training Task-Based Performance | Prior to the intervention, immediately following intervention, and 6 months after intervention completion. | Changes in neuropsychological functioning, as measured by the train-to-task activity. |
| Processing Speed | Prior to the intervention, immediately following intervention, and 6 months after intervention completion. | Changes in processing speed as measured by the NIH toolbox. |
| Attention | Prior to the intervention, immediately following intervention, and 6 months after intervention completion. | Changes in attention as measured by the NIH toolbox. |
| Working Memory | Prior to the intervention, immediately following intervention, and 6 months after intervention completion. | Changes in working memory as measured by the NIH toolbox. |
Countries
United States
Contacts
CONTACTEmily J Amsden, BS
PRINCIPAL_INVESTIGATORRachel K Peterson, PhD
Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Outcome results
None listed