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Carotid Intima-media Thickness in Dialysis Patients and Traditional Risk Factors

Association of Traditional Cardiovascular and Dialysis-Specific Risk Factors With Carotid Intima-Media Thickness in Hemodialysis Patients: A Cross-Sectional Study"

Status
Not yet recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07558239
Enrollment
100
Registered
2026-04-30
Start date
2026-04-24
Completion date
2026-07-01
Last updated
2026-04-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atherosclerosis, Dialysis Patients, Hypertension

Keywords

Renal dialysis, Carotid intima- media thickness

Brief summary

* Cardiovascular disease (CVD) is the leading cause of mortality in hemodialysis (HD) patients. * Carotid intima-media thickness (CIMT) is a validated surrogate marker for atherosclerosis. * Both traditional cardiovascular risk factors (hypertension, diabetes, dyslipidemia) and dialysis-specific factors (mineral metabolism disorders, dialysis duration) contribute to vascular damage.

Detailed description

* Cardiovascular disease (CVD) is the leading cause of mortality in hemodialysis (HD) patients. * Carotid intima-media thickness (CIMT) is a validated surrogate marker for atherosclerosis. * Both traditional cardiovascular risk factors (hypertension, diabetes, dyslipidemia) and dialysis-specific factors (mineral metabolism disorders, dialysis duration) contribute to vascular damage. * Gap in knowledge: Few studies have comprehensively assessed the combined impact of these factors on CIMT in HD patients.

Interventions

OTHERUltrasound measurements of carotid intima- media thickness

Ultrasound measurements of carotid intima- media thickness

Sponsors

Minia University
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No

Inclusion criteria

* 1\. Age 18 or older. 2. Patients with sepsis without AKI at the time of admission.

Exclusion criteria

* o Active malignancy * Acute infections * Recent cardiovascular events (\<3 months) * Poor echocardiographic window for CIMT measurement

Design outcomes

Primary

MeasureTime frame
• To determine the association between carotid intima - media thickness and: o Hypertension duration o HbA1c o LDL/HDL ratio o Dialysis duration o Parathyroid hormone (PTH) levels6 month

Secondary

MeasureTime frame
• To compare CIMT between: o Diabetics vs. non-diabetics o Short (<5 yrs) vs. long (≥5 yrs) dialysis duration o Patients with vs. without hyperparathyroidism (PTH >300 pg/m6month

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: May 1, 2026