Bispectral Index Monitoring, Burst Suppression, Total Intravenous Anesthesia
Conditions
Brief summary
The purpose of this study is to understand whether certain brain activity patterns that can appear at the beginning of anesthesia are related to how deep anesthesia remains during the operation. The main question of the study is: Do patients who show a pattern called burst suppression during the start of anesthesia experience deeper anesthesia during surgery? Patients who are scheduled for elective surgery under total intravenous anesthesia (TIVA) may take part in this study. During the operation, brain activity will be monitored using a sensor placed on the forehead (Bispectral Index, BIS monitor), which is already commonly used during anesthesia. Information such as BIS values and the doses of anesthesia medications given during the operation will be recorded. Participation in this study will not change the type of anesthesia or the routine care that patients receive during surgery. The study only involves recording and analyzing information collected during standard anesthesia monitoring.
Interventions
None listed
Sponsors
Amasya University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Age between 18 and 75 years * American Society of Anesthesiologists (ASA) physical status I-III * Scheduled for elective surgery * Surgery planned to be performed under total intravenous anesthesia (TIVA)
Exclusion criteria
* Presence of neurological disease * Chronic use of sedative medications or antiepileptic drugs * Severe hepatic or renal dysfunction * Intraoperative administration of ketamine or dexmedetomidine
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| TBIS<40 | During intraoperative period | Total duration during the maintenance phase of anesthesia in which the BIS remains below 40, expressed as a proportion of total surgical time, compared between patients with and without burst suppression during induction |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| TBIS40-60 | During intraoperative period | Duration during maintenance anesthesia in which BIS values remain between 40 and 60, expressed as a proportion of total surgical time. |
| TBIS>60 | During intraoperative period | Duration during maintenance anesthesia in which BIS remains above 60, expressed as a proportion of total surgical time. |
| TLOC | During induction of anesthesia | Time to loss of consciousness :Time from induction agent administration to loss of consciousness. Loss of consciousness is defined as the moment when both the eyelash and corneal reflexes are abolished, and the time was recorded in seconds. |
| BIS-LOC | At the exact time of loss of consciousness (LOC) | Bispectral Index (BIS) value at the time of loss of consciousness following induction of anesthesia. Loss of consciousness is defined as the moment when both the eyelash and corneal reflexes are abolished |
| TROC | During emergence from anesthesia | Time to return of consciousness:Time from discontinuation of anesthetic agents during the maintenance phase of anesthesia to return of consciousness. Return of consciousness was defined as the moment when the patient regained consciousness, demonstrated by eye opening and/or response to verbal commands, and the time was recorded in seconds |
| BIS-ROC | At the moment of response to verbal commands during emergence from anesthesia | Bispectral Index (BIS) value at the timeof return of consciousness. Return of consciousness was defined as the moment when the patient responded to verbal commands. |
| Propofol infusion rate during anesthesia | During the intraoperative period | Propofol administration will be recorded at 1-minute intervals throughout the intraoperative period. Additionally, total drug consumption during the procedure will be obtained from infusion pump records. Values recorded at 1-minute intervals will be used for time-based correlation analyses, while infusion pump data will be used to calculate mean infusion rates. The total amount of propofol administered during the entire surgical procedure will be calculated and expressed as mg/kg/hour. |
| Remifentanil infusion rate during anesthesia | During the intraoperative period | Remifentanil administration will be recorded at 1-minute intervals throughout the intraoperative period. Additionally, total drug consumption during the procedure will be obtained from infusion pump records. Values recorded at 1-minute intervals will be used for time-based correlation analyses, while infusion pump data will be used to calculate mean infusion rates. The total amount of remifentanil administered during the entire surgical procedure will be calculated and expressed as µg/kg/min |
Countries
Turkey (Türkiye)
Contacts
CONTACTBülent Meriç Çam, MD
Outcome results
None listed