Intracerebral Haemorrhage, Ischemic Stroke, Paediatric Stroke, Stroke, Stroke Acute
Conditions
Keywords
Stroke, ischemic stroke, Intracerebral Hemorrhage, Paediatric Stroke, Cerebrovascular Disorders, Brain Diseases, Vascular Diseases, Cardiovascular Diseases, Brain Infarction, Embolic Stroke, Thrombotic Stroke, Acute
Brief summary
The Stroke-CORE cohort aims to provide a comprehensive and up-to-date understanding of stroke care in Germany. To achieve this, patients are followed along the entire continuum of care-from initial management before hospital admission, through acute treatment, rehabilitation, and follow-up care, to the prevention of recurrent strokes. Strokes occurring in childhood are also included in this cohort study. In addition, the study seeks to establish effective structures for the early identification and inclusion of patients in clinical research (screening). In this context, structured screening processes are being implemented across all levels of care at participating sites within the Network University Medicine (NUM), a collaboration of German university hospitals. At the same time, the cohort serves as a platform within this network to systematically address open research questions in various areas of stroke care and to support the targeted planning and conduct of future clinical studies. The study includes patients with ischemic stroke (caused by a blocked blood vessel) or intracerebral hemorrhage (bleeding within the brain). Participation takes place in different thematic modules, each focusing on specific aspects of the disease course and its management. These modules address, among other topics, acute hospital treatment, measures to prevent recurrent strokes (secondary prevention), possible complications, pre-hospital care, rehabilitation, follow-up care, and long-term outcomes such as physical recovery, independence in daily life, and cognitive functions including memory and concentration. As part of the study, a range of data is collected. This includes sociodemographic information (such as age and living situation) as well as medical data, for example on prior conditions, diagnoses, treatments, and comorbidities. In addition, patients' health status is assessed at multiple time points in order to better understand the course of the disease. Depending on the level of participation, data collection may be complemented by the collection of biological samples, such as blood. These are obtained either during routine clinical procedures or through simple, minimally burdensome (non-invasive) methods. The study is structured into several levels that differ in the scope and depth of data collection. The basic level includes essential information, while higher levels involve more detailed assessments. In addition, some levels include the collection of biological samples, and there are optional supplementary modules in which patients may participate voluntarily. This tiered approach allows participation to be flexibly adapted to the individual situation while contributing to a nuanced and comprehensive understanding of stroke care.
Interventions
None listed
Sponsors
Charite University, Berlin, Germany
Universitätsklinikum Hamburg-Eppendorf
University Hospital Schleswig-Holstein
Wuerzburg University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Diagnosis of AIS or ICH; the AIS diagnosis may be diagnosed clinically or radiologically (i.e., focal neurological impairment of sudden onset, lasting more than 24 hours and of presumed vascular origin, or with proof of cerebral ischaemia corresponding to the clinical symptoms in neuroimaging); for ICH diagnosis requires clinical symptoms and radiological diagnosis of ICH * Hospital admission \<24h after symptom onset * Age 18+ years for the basic Modules AIS and ICH; age \<18 years for the basic Module paediatric stroke patients * Informed consent: Signed IC from patients capable of giving consent and understanding all content of the IC or IC of an appropriate patient representative or deferred consent, if patients are unable to consent themselves * Additional inclusion criteria are defined by the individual Modules
Exclusion criteria
* In-hospital stroke * TIA * SAH * Stroke as a complication of a medical procedure * Enrolment in a randomised placebo-controlled interventional trial * Already enrolled in the SN STROKE base cohort
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| adaptive research platform addressing various and for the 3 groups different research questions | Depending on the group, outcome measures will be collected through study completion, primarily at baseline, follow-up at 3 and/or 6 months, and annually, with an average follow-up period expected to be 1 year. | Outcomes include disease severity, standard of care, complications, recurrent ischaemic or haemorrhagic stroke, burden and impact of disease and treatment on quality of life, functional outcome and survival at different time points. Since SN Stroke is an adaptive research platform addressing various research questions, additional outcomes and different determinants influencing these outcomes may be added in each module. |
Countries
Germany
Contacts
CONTACTJohanna-Luise Kanwisch
CONTACTClaudia Kunze
PRINCIPAL_INVESTIGATORKaren Gertz, Full professor, MD
Charite University, Berlin, Germany
PRINCIPAL_INVESTIGATORGoetz Thomalla, Full professor, MD
Universtätsklinikum Hamburg Eppendorf, Germany
Outcome results
None listed