Multimodal CT-Based Risk Stratification for Postoperative Local Recurrence in NSCLC: A Multicenter Study

Multimodal CT-Based Risk Stratification of Postoperative Local Recurrence in Non-Small Cell Lung Cancer: A Multicenter Study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07552532

Enrollment

2000

Registered

2026-04-27

Start date

2023-01-01

Completion date

2026-06-01

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung Cancer (NSCLC)

Keywords

local recurrence, risk stratification, radiomics, deep learning

Brief summary

This multicenter retrospective study is designed to develop and validate a CT-based multimodal risk stratification approach for postoperative local recurrence after curative-intent resection of non-small cell lung cancer (NSCLC). The approach integrates clinicopathologic variables, intratumoral and peritumoral radiomics, tumor-based 2.5D deep learning features, whole-lung deep learning features, and operative text features to capture complementary information related to tumor phenotype, pulmonary background, and surgical findings. Predictive performance and clinical utility will be evaluated in internal and external validation cohorts using the concordance index, time-dependent area under the receiver operating characteristic curve, decision curve analysis, and risk reclassification analyses. The objective of this study is to assess whether multimodal CT-based risk stratification may improve postoperative risk assessment and support individualized surveillance and management strategies.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Pathologically confirmed non-small cell lung cancer (NSCLC) 2. Preoperative contrast-enhanced chest CT performed within 2 weeks before surgery 3. Underwent routine postoperative follow-up

Exclusion criteria

1. Small cell lung cancer or metastatic tumors 2. Incomplete resection (R1/R2) 3. No preoperative contrast-enhanced CT performed within 2 weeks before surgery 4. History of other malignancies 5. Inadequate follow-up or follow-up duration of 3 months or less

Design outcomes

Primary

Measure	Time frame
Postoperative local recurrence	From the date of surgery to first documented local recurrence, up to 3 years

Countries

China

Outcome results