Age-related Cataract
Conditions
Brief summary
The goal of this observational study is to evaluate the location of phacoemulsification tip measured by intraoperative OCT during cataract surgeries and its impact on early postoperative changes of cornea and visual acuity. The main question it aims to answer is: In patients with age-related cataracts undergoing phacoemulsification, does the location (supracapsular, iris-lens diaphragm, or endocapsular) of the phaco tip affect postoperative corneal changes and visual acuity at early postoperative stage? Eyes having phacoemulsification for cataracts will receive intraoperative OCT imaging to evaluate the location of the phaco tip during surgery, and corneal changes and visual acuity will be measured postoperatively.
Interventions
PROCEDUREcataract surgery
Cataract phacoemulsification combined with intraocular lens implantation
Sponsors
Zhongshan Ophthalmic Center, Sun Yat-sen University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
50 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Age ≥ 50 years and ≤ 90 years * Diagnosis of unilateral/bilateral age-related cataract * Nuclear grade ≥2 in LOCSIII classification * Scheduled for cataract phacoemulsification combined with intraocular lens implantation * Pupil size ≥6mm after dilation * Corneal endothelial cell count ≥1500 cells/mm²
Exclusion criteria
* Diagnosis of severe systemic disease (e.g., severe hypertension or Alzheimer's disease) * History of ocular trauma or surgery * Presence of other ocular diseases (such as glaucoma, diabetic retinopathy, or high myopia) * Other ocular factors that may complicate the surgery (such as small pupil, shallow anterior chamber)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in corneal thickness | postoperative day 1, week 1, and month 1 | Corneal thickness measured by corneal endothelial specular microscope |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in corneal endothelial cell density | 1 day, 1 week, and 1 month postoperatively | Measured using corneal endothelial specular microscope |
| Best-corrected visual acuity | 1 day, 1 week, and 1 month postoperatively | Measured using ETDRS visual acuity protocol with ETDRS visual acuity chart by a masked examiner |
| Intraoperative and postoperative complications | Intraoperative, 1 day, 1 week, and 1 month postoperatively | Monitored by cataract surgeons using intraoperative OCT and postoperative slit-lamp examination. Complications include Descemet membrane detachment, posterior capsule rupture, incision leakage, and etc. |
Countries
China
Outcome results
None listed