The Effect of Periurethral Injection of Platelet Rich Plasma Versus Mid-urethral Sling in Treatment of Stress Urinary Incontinence

The Effect of Periurethral Injection of Platelet Rich Plasma Versus Mid-urethral Sling in Treatment of Stress Urinary Incontinence : a Randomized Clinical Trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07550426

Enrollment

Registered

2026-04-24

Start date

2026-04-15

Completion date

2027-12-30

Last updated

2026-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stress Urinary Incontinence (SUI)

Brief summary

this study used to compare efficacy between platelet rich plasma periurethral injection versus mid urethral sling ( trans obturator tape ) in treatment of stress urinary incontinence

Detailed description

stress urinary incontinence classified in urodynamic study according to Valsalva leak point pressure to intrinsic sphincteric muscle weakness best treated by PRP periurethral injection and VLPP is less than or equal 60cmH2O and MUCP less than 20cmH2O(21 ) patients enrolled in this group , while hypermobile urethra identified by VLPP is high more than 90cmh2O best treated by trans obturator tape(21) patients recruited in this group , mode of preparation of PRP is by withdrawing 15 ml blood and placed in falcon tube with ACD ( acid citrate dextrose) added centrifuged first at 800 RPM and then the supernatant removed and re-centrifuged again at 3500 RPM and then injected periurethral by 5cc syringe with 30G needle after applying 2% lidocaine ,patient assessed at one and three month objectively by cough stress test and subjectively by ICIQ questionnaire and presence of any adverse effect

Interventions

PROCEDUREPlatelet Rich Plasma

GROUP 1 : 21patient will have platelet rich plasma injected periurethral in intrinsic muscle weakness in stress urinary incontinence

PROCEDUREMid urethral sling ( trans obturator tape)

GROUP 2 : (21) patient having SUI due to hypermobile urethra will have TOT

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Intervention model description

randomized controlled clinical trial

Eligibility

Sex/Gender

FEMALE

Age

26 Years to 66 Years

Healthy volunteers

Inclusion criteria

* stress urinary incontinence identified by urodynamic study * patient agreement to undergo surgical treatment

Exclusion criteria

* previous GUS operation * evidence of detrusor overactivity urinary system * presence of pelvic organ prolapse * malignancies of genitourinary system * history of hemorrhagic disorders , on anti platelet treatment , uncontrolled diabetes mellitus .

Design outcomes

Primary

Measure	Time frame
objective assessment of urinary leakage through cough stress test	after one and three months

Countries

Egypt

Contacts

STUDY_DIRECTORmohamed A N, MD

urogynecology unit ainshams university

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jul 23, 2026