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Trial of Labor After One Cesarean Section a Cross-sectional Study After Protocol Introduction

Trial of Labor After Cesarean

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07549971
Acronym
TOLAC
Enrollment
1200
Registered
2026-04-24
Start date
2015-01-01
Completion date
2026-01-01
Last updated
2026-04-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Trial of Labor After Cesarean, Trial of Labor; Failure

Keywords

trial of labor after cesarean, failure of labor, induction of labor after cesarean

Brief summary

in 2015 a protocol for trail of labor after a single cesarean delivery was approved by medical committee of Pescara Hospital. A database from outpatient clinic evaluated all women after 34 weeks' gestation with a previous cesarean delivery. Patients with a specific medical indication for cesarean delivery were skipped, whilst the others were recruited within repetitive elective cesarean delivery or trial of labor based on maternal request. Patients were couselled on the opportunity of having a mechanical induction/ rupture of membranes and subsequent oxytocin infusion if needed due to prolonged gestation (above 41 weeks plus 3 days) or medical indication to delivery (i.e. gestational diabetes, hypertension, SGA, etc.)

Detailed description

All pregnant women with a previous CD attending Labor Ward of Santo Spirito Hospital of Pescara Italy (affiliated to University of Chieti Pescara) were enrolled at outpatient clinic after internal protocol registration for trial of labor in previus cesarean delivery. Patinets with a medical indication to CD were not elegible. Sociodemographic data such as ethnic background, maternal age, gestational age at delivery, previous vaginal birth, indications to previous CD, and maternal willingness to RECD ot TOLAC were recorded. Maternal decision to switch to different intervention were recorded. Outcome of RECD and TOLAC were recorded.

Interventions

PROCEDURErepetitive elective CD

maternal and neonatal outcomes

Sponsors

G. d'Annunzio University
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
FEMALE
Age
18 Years to 57 Years
Healthy volunteers
No

Inclusion criteria

* pregnant women * previous CD

Exclusion criteria

* below 34 weeks' gestation * medical indication to CD

Design outcomes

Primary

MeasureTime frameDescription
incidence of maternal request for trial of labor11 yearsincidence of women with request of trial of labor through the time
incidence of VBAC11 yearsnumber of vaginal birth through the time

Secondary

MeasureTime frameDescription
maternal adverse outcome11 yearsmaternal adverse outcome such as PPH, emergency CS, surgical complications
neonatal adverse outcome11 yearsNICU stay, low APGAR score (\<7 at 5'), fetal death

Contacts

PRINCIPAL_INVESTIGATORClaudio Celentano, MD

University of Chieti Pescara School of Medicine

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 25, 2026