Long Anterior Zonules
Conditions
Brief summary
Long anterior zonules (LAZ) is an anatomical anomaly of the anterior segment in which zonular fibers extend abnormally forward onto the anterior lens capsule. It is potentially associated with glaucoma, late-onset retinal degeneration, and increased risks during cataract surgery. This study introduces a 3D visualization system to enhance the detection rate of LAZ. By integrating multiple imaging modalities, it systematically assesses the morphological characteristics of LAZ, aiming to provide an evidence-based foundation for subsequent efforts to establish diagnostic consensus, optimize preoperative assessments for glaucoma and cataract surgery. By elucidating the genetic mechanisms and genotype-phenotype correlations of LAZ, this research can provide theoretical support for the early identification of high-risk populations, genetic consultation, and personalized treatment.
Interventions
GENETICControl
Routine cataract patient, no signs of LAZ, intraocular pressure ≤21 mmHg, and no history of glaucoma, pigment dispersion syndrome, or other eye diseases that clearly affect the anterior segment structure.
GENETICLong anterior zonules
Patients with cataracts combined with LAZ were independently evaluated by at least two senior ophthalmologists under slit-lamp examination or a 3D visualization system, and were required to meet the predefined diagnostic criteria for LAZ.
GENETICLAZ Pedigree
First-degree and above relatives of the LAZ proband, aged ≥18 years, regardless of the presence or absence of LAZ or related ocular disease phenotypes.
Sponsors
Fuzhou Eye Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Control Group Routine cataract patient, no signs of LAZ, intraocular pressure ≤21 mmHg, and no history of glaucoma, pigment dispersion syndrome, or other eye diseases that clearly affect the anterior segment structure. * LAZ Group Patients with cataracts combined with LAZ were independently evaluated by at least two senior ophthalmologists under slit-lamp examination or a 3D visualization system, and were required to meet the predefined diagnostic criteria for LAZ. * LAZ Pedigree Cohort First-degree and above relatives of the LAZ proband, aged ≥18 years, regardless of the presence or absence of LAZ or related ocular disease phenotypes.
Exclusion criteria
* Secondary glaucoma with a clear etiology (such as inflammatory, traumatic, or neovascular glaucoma, etc.) * History of previous intraocular surgery (e.g., cataract, glaucoma, or vitreoretinal surgery), with refractive surgery history documented but analyzed with caution * Presence of ocular conditions affecting anterior segment imaging quality, such as corneal leukoma or severe cataract * Individuals with severe systemic diseases (e.g., poorly controlled diabetes, connective tissue diseases) or mental disorders that hinder cooperation during examinations * Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Axial length | 1 day pre-op | Axial length, anterior chamber depth, lens thickness, corneal curvature, corneal diameter |
| Anterior chamber depth | 1 day pre-op | — |
| Lens thickness | 1 day pre-op | — |
| Corneal curvature | 1 day pre-op | — |
| Corneal diameter (WTW) | 1 day pre-op | — |
| Imaging of LAZ morphology and distribution | 1 day pre-op | The images and videos about slit lamp and 3D visualization system. |
| Gene sequencing | through study completion, an average of 1 year | Identification of pathogenic genes |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Uncorrected Visual Acuity (UCVA) | 1 day pre-op; 1 day post-op; 7 days post-op; 30 days post-op | — |
| Corrected Distance Visual Acuity (CDVA) | 1 day pre-op; 1 day post-op; 7 days post-op; 30 days post-op | — |
| Spherical equivalent (SE) | 1 day pre-op; 1 day post-op; 7 days post-op; 30 days post-op | — |
| Intraocular pressure | 1 day pre-op; 1 day post-op; 7 days post-op; 30 days post-op | — |
| Intraoperative complications | Intraoperative | Intraoperative capsular complications occur |
| Age | 1 day pre-op | — |
| Sex | 1 day pre-op | — |
| Diagnosis | 1 day pre-op | Diagnosis of accompanying ocular and systemic conditions, such as glaucoma, macular degeneration, hypertension, diabetes, etc. |
| Anterior chamber volume (ACV) | 1 day pre-op | — |
| Anterior chamber area (ACA) | 1 day pre-op | — |
| Angle opening distance (AOD) | 1 day pre-op | — |
| Trabecular iris angle (TIA) | 1 day pre-op | — |
| Images of the ciliary body structure | 1 day pre-op | Images of the ciliary body captured by UBM |
Countries
China
Outcome results
None listed