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Ozone Oil-based Gel and CHX Gel After Lower Third Molar Removal

Comparing Ozone Oil-based Gel and CHX Gel Applications to Reduce Pain and Incidence of Dry Socket After Lower Third Molar Extraction, a Randomized Clinical Study

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07549672
Enrollment
100
Registered
2026-04-24
Start date
2023-07-01
Completion date
2026-09-01
Last updated
2026-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dry Socket, Pain

Keywords

Dry socket, Pain, Lower third molar

Brief summary

Overall, 100 patients of both genders were included in the study, with indication of surgical extraction of lower third molar, positioned similarly after being clinically and radiographically checked by X-ray and orthopantomography. Each patient was subjected to both groups in separate sessions: treated with ozone gas and with CHX gel 1%. Data on pain intensity, number of taken analgesics- painkillers, and dry socket were recorded for 48 h and at Day 7

Detailed description

Overall, 100 patients of both genders were included in the study, with indication of surgical extraction of lower third molar, positioned similarly after being clinically and radiographically checked by X-ray and orthopantomography. Each patient was subjected to both groups in separate sessions: treated with ozone gas and with CHX gel 1%. Data on pain intensity, number of taken analgesics- painkillers, and dry socket were recorded for 48 h and at Day 7

Interventions

DRUGOzone Oil-based Gel

Overall, 30 patients of both genders were included in the study, with indication of surgical extraction of lower third molar, positioned similarly after being clinically and radiographically checked by X-ray and orthopantomography. Each patient was subjected to both groups in separate sessions: treated with ozone gas and with CHX gel 1%. Data on pain intensity, number of taken analgesics- painkillers, and dry socket were recorded for 48 h and at Day 7

Sponsors

Cairo University
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE

Intervention model description

Overall, 100 patients of both genders were included in the study, with indication of surgical extraction of lower third molar, positioned similarly after being clinically and radiographically checked by X-ray and orthopantomography. Each patient was subjected to both groups in separate sessions: treated with ozone gas and with CHX gel 1%. Data on pain intensity, number of taken analgesics- painkillers, and dry socket were recorded for 48 h and at Day 7

Eligibility

Sex/Gender
ALL
Age
21 Years to 35 Years
Healthy volunteers
Yes

Inclusion criteria

* Patients with third impacted bilateral molars, symmetrically in the same position, position evaluated by radiography. * Patients in whom operative extraction of third molars is indicated with the creation of a mucoperiosteal flap. * Patients regardless of gender.

Exclusion criteria

* Voluntary exclusion of the patient. * lack of cooperation in any of the work phase

Design outcomes

Primary

MeasureTime frameDescription
pain severity7 dayspain scale ( VAS ; visual analogue scale) (1-10)

Secondary

MeasureTime frameDescription
dry socket incidence15 daaysbare socket (binary yes/no)

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 29, 2026