Bidirectional Cohort Study of a Prognosis Model for Acute-on-chronic Liver Failure

Bidirectional Cohort Study on Prognostic Model Construction for Acute-on-Chronic Liver Failure

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07548190

Enrollment

2000

Registered

2026-04-23

Start date

2018-01-01

Completion date

2026-12-31

Last updated

2026-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver Failure

Brief summary

This study constitutes a bidirectional cohort investigation. By collating laboratory parameters and clinical data-including plasma and peripheral blood mononuclear cell (PBMC) analyses-from patients with acute-on-chronic liver failure, it aims to provide a reference framework for predicting prognosis and the occurrence of complications.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

18 Years to 85 Years

Healthy volunteers

Inclusion criteria

•Clinical diagnosis of Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF)

Exclusion criteria

* age \< 18 years * extrahepatic organ failure unrelated to ACLF * active malignancy * co-infection with other hepatitis viruses or human immunodeficiency virus (HIV) * prior liver transplantation * use of immunosuppressants within 6 months before enrollment * unclear history of antiviral therapy

Design outcomes

Primary

Measure	Time frame
Primary endpoint was all-cause mortality at days 28, 90, 180, and 360.	Days 28, 90, 180, and 360

Countries

China

Contacts

STUDY_DIRECTORShan Zhong, professor

Department of Infectious Diseases, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, The Second Affiliated Hospital, Chongqing Medical University

Outcome results