Healthy
Conditions
Brief summary
This study examines whether a single session of exergaming-based seated Tai Chi can acutely improve working memory, executive function, and prefrontal cortical efficiency in younger and older adults, compared with seated stretching. Using a within-subject crossover design, 40 participants aged 18-30 years and 60-75 years will complete both conditions in counterbalanced order on separate days. Cognitive performance will be assessed with Flanker and n-back tasks, while prefrontal activity will be recorded with fNIRS over the dorsolateral, ventrolateral, and frontopolar prefrontal cortex. Neural efficiency will be estimated by integrating task performance with task-evoked oxygenated hemoglobin responses. The Tai Chi intervention is a 40-minute seated, exergame-guided 12-form routine preceded and followed by brief warm-up and cool-down periods. The control condition is a time-matched seated stretching programme without Tai Chi-specific movements or game feedback. Both conditions will be delivered at light-to-moderate intensity and supervised for safety and adherence. The study tests whether acute exergaming-based seated Tai Chi produces greater post-intervention improvements in cognitive performance and more efficient prefrontal activation than stretching, and whether these effects differ by age group. Findings may clarify how a feasible seated mind-body exergame influences acute cognitive and neural responses across the adult lifespan.
Detailed description
This proposal examines the immediate cognitive and neural effects of a seated, exergame-supported Tai Chi session in younger and older adults. The study is designed to test whether a single bout of this low-impact mind-body exercise can influence working memory, inhibitory control, and prefrontal cortex activity more effectively than a seated stretching session of equal duration. By comparing two age groups, the project also seeks to determine whether age modifies the size or pattern of these acute responses. The study uses a randomized within-subject crossover design, in which each participant completes both the exergaming-based seated Tai Chi condition and the control stretching condition on separate days. Forty older adults will be recruited, including 20 younger adults aged 18-30 years and 20 older adults aged 60-75 years. Before and after each session, participants will complete computerized cognitive tasks measuring executive function and working memory. At the same time, brain activity will be monitored with functional near-infrared spectroscopy, focusing on prefrontal regions linked to attention, control, and task monitoring. The Tai Chi session is delivered through an interactive exergame platform that standardizes movement pace, provides visual and auditory cues, and includes a structured sequence of seated Tai Chi forms. This format is intended to preserve the cognitive-motor features of Tai Chi while making the activity accessible to adults who may have limited mobility. The comparison condition consists of seated stretching exercises matched for overall duration and physical effort but without Tai Chi-specific sequencing or game-based feedback. Outcome analysis will compare changes in task performance, prefrontal oxygenation, and a combined neural efficiency index across conditions, time points, and age groups. The study aims to clarify whether this form of seated exergaming can produce measurable short-term benefits for cognition and brain efficiency, and whether such effects differ between younger and older adults.
Interventions
BEHAVIORALExergaming based sitting Tai Chi
An acute exergaming-based seated Tai Chi protocol will be adapted from a newly developed 12-week training programme by our team, and will be further aligned with acute Tai Chi session parameters reported by a previous Tai Chi study, including comparable total duration, work-rest structure, and target light-to-moderate intensity. Participants will perform upper-limb and trunk movements derived from traditional Tai Chi forms, adapted for a seated posture and integrated into an interactive exergame environment that provides visual feedback and performance scoring to enhance engagement and standardize practice. Movements will be paced using on-screen cues and visual and auditory signals to control tempo across participants.
BEHAVIORALSeated Stretching
In the seated stretching condition, participants will complete a series of structured, low-intensity exercise program that would contain comparable social interaction and enjoyment without providing any strength and balance training benefits of Tai Chi. This will match in overall duration and approximate movement amplitude to the Tai Chi sequence but without game-based feedback or Tai Chi-specific components.
Sponsors
Hong Kong Metropolitan University
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* Are aged 18-30 years (young adult group) or 60-75 years (older adults) * Have no current regular participation (e.g., ≥1 session/week) in Tai Chi, martial arts, or other mind-body exercise (e.g., yoga or qigong) in the last 3-6 months * Have no self-reported or clinically documented history of mild cognitive impairment, dementia, or other neurological (e.g., stroke) or psychiatric disorders (e.g., schizophrenia) known to affect cognition * Score within the normal range on the Hong Kong version of Montreal Cognitive Assessment (HK-MoCA) based on established age- and education-adjusted cutoffs * Are medically stable, with or without controlled chronic conditions (e.g., controlled hypertension or diabetes) * Are able to tolerate light-to-moderate seated exercise (Chinese version of Physical Activity Readiness Questionnaire score = 0) * Have no significant sensory impairment (e.g., vision) not corrected by assistive devices (e.g., glasses) * Are not engaged in regular structured exercise involving moderate-to-vigorous intensity physical activity (e.g., brisk walking, running, or racquet sports) more than two times per week over the preceding three months * Are able to communicate in Chinese (Moved from Exclusion for clarity)
Exclusion criteria
* Have medical conditions that may interfere with safe participation, including pacemaker implantation or prosthetic devices * Have serious orthopedic or cardiovascular disorders that could affect participation in exergaming training * Have significant motor or balance impairment that would prevent performing basic seated arm and trunk movements * Are currently undergoing other clinical trials or structured exercise or cognitive training programmes \>2 times/week during the preceding three months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prefrontal cortical activation during inhibitory control (Flanker task) | Baseline (pre-session) and immediately post-session on 2 consecutive days (Day 1 and 2). | Prefrontal cortical activity (oxyhemoglobin concentration, µM) will be recorded using functional near-infrared spectroscopy (fNIRS) during the Eriksen Flanker Task, which assesses inhibitory control. Regions of interest include the dorsolateral prefrontal cortex (DLPFC), ventrolateral prefrontal cortex (VLPFC), and frontopolar prefrontal cortex (FPC). Measurements will be taken before and immediately after a single session of exergaming-based seated Tai Chi and a single session of seated stretching in a crossover design. Data will be reported separately for each condition. Unit of Measure: µM (micromolar) oxyhemoglobin concentration. |
| Prefrontal cortical activation during working memory (n-back task) | Baseline (pre-session) and immediately post-session on 2 consecutive days (Day 1 and Day 2) | Prefrontal cortical activity (oxyhemoglobin concentration, µM) will be recorded using functional near-infrared spectroscopy (fNIRS) during the n-back Task, which assesses working memory. Regions of interest include the dorsolateral prefrontal cortex (DLPFC), ventrolateral prefrontal cortex (VLPFC), and frontopolar prefrontal cortex (FPC). Measurements will be taken before and immediately after a single session of exergaming-based seated Tai Chi and a single session of seated stretching in a crossover design. Data will be reported separately for each condition. Unit of Measure: µM (micromolar) oxyhemoglobin concentration. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Inhibitory Control Performance on the Eriksen Flanker Task - reaction time | Baseline (Pre-Session) and Immediately Post-Session on 2 consecutive days (Day 1 and Day 2) | Inhibitory control will be assessed using the computerized Eriksen Flanker Task. Participants will respond to the direction of a central target arrow flanked by congruent or incongruent distractor arrows. Reaction time (milliseconds) will be recorded for incongruent and congruent trials. The outcome metric is the difference in mean reaction time between incongruent and congruent trials (Flanker cost in milliseconds). Lower or less positive values indicate better inhibitory control. Unit of Measure: milliseconds |
| Working Memory Performance on the n-back Task - reaction time | Baseline (Pre-Session) and Immediately Post-Session on 2 consecutive days (Day 1 and Day 2). | Working memory capacity will be assessed using the computerized n-back Task (e.g., 2-back). Participants will view a sequence of stimuli and indicate whether the current stimulus matches the one presented n positions earlier. Reaction time (milliseconds) will be recorded for each correct response. Lower values indicate better performance (faster responses). The primary metric is the mean reaction time across all trials. |
| Title: Working Memory Performance on the n-back Task - Accuracy | Baseline (Pre-Session) and immediately post-session on 2 consecutive days (Day 1 and Day 2). | Working memory capacity will be assessed using a computerized n-back task (e.g., 2-back). Participants will view a sequence of stimuli and indicate whether the current stimulus matches the one presented n positions earlier. Accuracy (percentage of correct responses) will be calculated. Higher values indicate better performance (fewer errors). The primary metric is the mean accuracy across all trials. |
| Inhibitory Control Performance on the Eriksen Flanker Task - Accuracy | Baseline (Pre-Session) and immediately post-session on 2 consecutive days (Day 1 and Day 2) | Inhibitory control will be assessed using the computerized Eriksen Flanker Task. Participants will respond to the direction of a central target arrow flanked by congruent or incongruent distractor arrows. Accuracy (percentage of correct responses) will be calculated for incongruent and congruent trials. The outcome metric is the difference in accuracy between incongruent and congruent trials (Flanker cost in percentage points). Higher or less negative values indicate better inhibitory control. Unit of Measure: percentage points |
Countries
Hong Kong
Contacts
CONTACTChun Yan Ho
PRINCIPAL_INVESTIGATORTai Wa Liu
School of Nursing and Health Sciences, Hong Kong Metropolitan University
Outcome results
None listed