Insulin Resistance
Conditions
Keywords
insulin resistance, HOMA-IR, pediatric surgery
Brief summary
It is a double blinded randomized controlled trial interventional study, examining the effect of carb loading given prior to surgery on preventing post operative insulin resistance in pediatric patients undergoing elective surgery
Detailed description
The tsudy
Interventions
OTHERCarbohydrate loading
Subjects, at 1 hour prior to surgery, are given liquid containing Dextrose10% with osmolality of 191,92mOsm/L and energy of 34 kcal/100 cc. The dose is 3 ml/kg body weight
OTHERWater (Placebo)
Subjects, at 1 hour prior to surgery, are given just water with the dose of 3 ml/kg body weight
Sponsors
Gadjah Mada University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Investigator)
Masking description
Only assessor are blinded to the masking. Participants are asked for consent to receive the intervention
Eligibility
Sex/Gender
ALL
Age
2 Years to 16 Years
Healthy volunteers
Yes
Inclusion criteria
* ASA Physical Status I and II * Able to tolerate enteral feeding * Subjects are undergoing surgery with general anesthesia
Exclusion criteria
* Subjects consume corticosteroids and insulin * Subjects have endocrine disorder, gastroesophageal reflux disease and psychiatric disorder * Subjects are treated with preoperative parenteral nutrition * The surgical procedure is longer than 4 hours Drop out Criteria: \- Intraoperative surgical emergency e.g. massive bleeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Insulin Resistance | measured just before incision and 24 hour after surgery | Insulin resistance is measured using Homeostasis Model Assessment Insulin Resistance (HOMA-IR), with the formula of (Insulin concentration x Glucose concentration)/22.5 |
Countries
Indonesia
Outcome results
None listed