Cervical Cancer Screening, Human Papilloma Virus (HPV)
Conditions
Brief summary
Patients indicated for subtotal hysterectomy will be tested for High risk HPV and if the result is positive will undergo expert colposcopy and conisation if not indicated otherwise at the time of subtotal hysterectomy
Interventions
None listed
Sponsors
General University Hospital, Prague
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* age over 18 * indication for subtotal hysterectomy * consent to provide conisation in case the HPV test result is positive
Exclusion criteria
* negative HPV test in the last 3 years
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Benefit of addition of HPV DNA testing before subtotal hysterectomy | 3 years | Prevalence of HPV positivity in the tested cohort (patients indicated for subtotal hysterectomy). Prevalence of HPV (other than HPV 16 and 18) positivity in the tested cohort (patients indicated for subtotal hysterectomy). Prevalence of abnormal oncological cytology result and correlation to HPV result in the tested cohort (patients indicated for subtotal hysterectomy). Prevalence of cervical intraepithelial leasions in patients who underwent cone biopsy with the subtotal hysterectomy. Prevalence of high grade cervical intraepithelial leasions in patients who underwent cone biopsy with the subtotal hysterectomy. Rate of HPV negativity 6 months after cone biopsy. |
Contacts
CONTACTTomas Fučík, M.D.
STUDY_DIRECTORLukáš Dostálek, M.D.
General Universty Hospital in Prague, Czech Republic
Outcome results
None listed