Glycemic Response to Feeding in Healthy Participants, Meal Timing, Postprandial Glucose
Conditions
Brief summary
This randomized crossover study aims to investigate the effect of circadian timing of a standardized meal (morning versus evening consumption) on postprandial glucose response in healthy adults. Postprandial glucose will be assessed using the incremental area under the curve (iAUC) over 120 minutes.
Interventions
The standardized test meal provided 50 g of carbohydrates of weighed portions of white bread and jam, served with 200 mL of water.
Sponsors
King Faisal University
Saudi Food and Drug Authority
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Healthy adults aged 18 years and older * Able and willing to provide informed consent * Able to comply with study procedures
Exclusion criteria
* Diagnosis of diabetes or any metabolic disorder affecting glucose regulation * Use of any medications * Pregnant or breastfeeding women * Night shift workers or individuals with irregular sleep patterns
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incremental Area Under the Curve (iAUC) for Postprandial Glucose | Baseline to 120 minutes after consumption of the standardized test meal | The primary objective of this study is to investigate the effect of circadian timing of a standardized test meal (morning versus evening consumption) on postprandial glucose response in healthy adults, assessed as the incremental area under the curve (iAUC) for capillary blood glucose over 120 minutes following meal consumption |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Peak Postprandial Glucose (Morning vs Evening) | Baseline to 120 minutes after consumption of the standardized test meal | Peak capillary blood glucose concentration measured within 120 minutes after consumption of the standardized test meal, under morning and evening conditions |
| Time to Peak Glucose (Morning vs Evening) | Baseline to 120 minutes after consumption of the standardized test meal | Time required to reach peak capillary blood glucose concentration following meal consumption, under morning and evening conditions. |
| Postprandial Glucose Profile (Morning vs Evening) | Baseline, 15, 30, 60, 90, and 120 minutes after consumption of the standardized test meal | Capillary blood glucose concentrations measured at predefined time points following consumption of the standardized test meal, under morning and evening conditions. |
Countries
Saudi Arabia
Contacts
CONTACTWafa Alotaibi, PhD
Outcome results
None listed