Effect of Positive End-Expiratory Pressure Titration on Venous Excess Ultrasound Score and Renal Outcomes in Patients With Acute Respiratory Distress Syndrome

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07545252

Enrollment

Registered

2026-04-22

Start date

2026-04-12

Completion date

2026-10-12

Last updated

2026-04-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Respiratory Distress Syndrome (ARDS)

Keywords

ARDS, mechanically ventilatuon, PEEP Titration, VExUS

Brief summary

This study is a prospective observational cohort study conducted planned to include 40 patients with ARDS to assess the effect of different levels of PEEP titration on VExUS score and renal outcomes in patients with Acute Respiratory Distress Syndrome.

Detailed description

This study is a prospective observational cohort study conducted planned to include 40 patients with ARDS within 24 hours of onset and mechanically ventilated for more than 24 hours to assess the effect of different levels of PEEP titration on Venous Excess Ultrasound Score and renal outcomes in patients with Acute Respiratory Distress Syndrome.

Interventions

OTHERVExUS score

The Venous Excess Ultrasound Score (VExUS) was calculated for each patient based on the assessment of systemic venous congestion using the following parameters: Inferior vena cava (IVC) diameter and respiratory collapsibility, Hepatic vein Doppler waveform, Portal vein Doppler pulsatility and Intrarenal venous Doppler pattern.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 18 Years

Healthy volunteers

Inclusion criteria

* Age ≥18 years. * Diagnosis of ARDS according to the Berlin criteria. * Invasive mechanical ventilation ≥24 hours. * Requirement of PEEP ≥5 cmH₂O.

Exclusion criteria

* Known end-stage renal disease on chronic dialysis. * History of renal transplantation. * Pregnancy. * Known severe tricuspid regurgitation. * Chronic liver disease with portal hypertension. * Poor ultrasound window precluding adequate venous Doppler assessment.

Design outcomes

Primary

Measure	Time frame	Description
VExUS score	3 days	Change in VExUS score in relation to different PEEP levels in mechanically ventilated patients with ARDS.
Development of acute kidney injury (AKI)	3 days	Development of acute kidney injury (AKI), defined and staged according to the KDIGO criteria: increase in serum creatinine by ≥0.3 mg/dL within 48 hours, or ≥1.5 times baseline within 7 days, or urine output \<0.5 mL/kg/hour for 6 hours.

Secondary

Measure	Time frame	Description
Requirement for renal replacement therapy (RRT) during ICU stay.	3 days	Requirement for renal replacement therapy (RRT) during ICU stay.
Length of ICU stay	4 to 7 days	Length of ICU stay
ICU mortality	4 to 7 days	ICU mortality during ICU Stay

Contacts

CONTACTHager R. Elsofey, MBBCh

hra13@fayoum.edu.eg+201153153624

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 23, 2026