Obesity (Disorder)
Conditions
Keywords
Obesity, PFAS, Environment
Brief summary
Childhood obesity is a particular concern in developed countries such as the United States, the United Kingdom, Canada, and certain European countries. According to the World Health Organization (WHO), approximately 6% of children under the age of 5 worldwide were obese in 2016, a figure that continues to rise. The pathophysiology of pediatric obesity can be explained by several interconnected biological and behavioral mechanisms. In particular, it involves dysfunctions in the hormones that regulate appetite and satiety, as well as dysfunctions in lipid metabolism. Per- and polyfluoroalkyl substances (PFAS) are a large family of synthetic chemical compounds. The main PFAS are perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), perfluorononanoic acid (PFNA), and perfluorohexanesulfonic acid (PFHxS). PFAS are present in many everyday consumer products. Bisphenol A (BPA) is a chemical compound used primarily in the manufacture of plastics and resins. It is commonly found in polycarbonate plastics, used to make food containers and water bottles, as well as in epoxy resins, which are used to coat the inside of food cans and water pipes. Non-persistent pesticides, such as organophosphates and polychlorinated biphenyls, are chemicals used primarily in agriculture to control insects and other pests. There are arguments suggesting that PFAS, bisphenol A, and non-persistent pesticides may play a role in the onset of pediatric obesity, particularly by acting.
Interventions
OTHERBlood test
Inclusion visit: during the routine blood test, one additional tube of blood will be collected for the study.
OTHERUrine sample
Inclusion visit: a urine sample will be collected for the study.
OTHERHair sample
Inclusion visit: a hair sample will be taken from the patient.
Sponsors
University Hospital, Tours
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
6 Years to 15 Years
Healthy volunteers
Yes
Inclusion criteria
Patient with Obesity disorder : * Children with obesity (according to the BMI curves of the International Obesity Task Force/IOTF) * Follow-up within the obesity network of the Centre Val de Loire region (ObeCentre) Control group: * Children who are not obese (according to the BMI curves of the International Obesity Task Force/IOTF) All: * Children aged 6 to 15 at the time of inclusion (inclusive) * Whose two parents, or legal guardian, have signed an informed consent form * Patients affiliated with or covered by a social security system
Exclusion criteria
* Disorder preventing understanding of trial information or informed consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| PFOA concentration | At the enrollment visit | Difference in plasma PFOA concentration measured in ng/mL between obese and non-obese children (control group). PFOA will be measured in plasma using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) at the Laberca laboratory. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| PFOS concentration | At the enrollment visit | Difference in plasma concentration of perfluorooctane sulfate (PFOS) measured in ng/mL between obese children and non-obese children. |
| PFNA concentration | At the enrollment visit | Difference in plasma concentration of perfluorononanoic acid (PFNA) measured in ng/mL between obese children and non-obese children |
| PFHxS concentration | At the enrollment visit | Difference in plasma concentration of perfluorohexanesulfonic acid (PFHxS) measured in ng/mL between obese children and non-obese children. |
| BPA concentration | At the enrollment visit | Differences in urinary BPA concentrations measured in ng/mL between obese and non-obese children |
| Non-persistent pesticides concentration | At the enrollment visit | Differences in urinary concentrations of non-persistent pesticides (organophosphates and polychlorinated biphenyls) in ng/mL between obese and non-obese children |
| Number of DNA breaks | At the enrollment visit | Differences in the number of DNA breaks in hair follicles between obese and non-obese children |
Countries
France
Contacts
CONTACTJulien LEJEUNE
CONTACTCoralie TAILLEBUIS
Outcome results
None listed