Knee Osteoarthritis (Knee OA)
Conditions
Keywords
Orthotic Devices, knee osteoarthritis
Brief summary
This study aims to examine the effects of moderate-intensity strength training, performed with or without an unloading knee orthosis (valgus-corrective or sham mode), on muscle function, motor unit behavior, and force modulation in patients with moderate knee osteoarthritis
Interventions
BEHAVIORALthe strengthening program
The isometric knee-extension strengthening program from session 1 to session 9 as follows: 1. Before the first training session each week, one-repetition maximum (1RM) will be measured to determine the training intensity for that week. 2. Training frequency: Three sessions per week on non-consecutive days, for a total of 3 weeks (9 sessions). 3. Training intensity: 60% of 1RM. The goal is to improve quadriceps strength and endurance while reducing joint loading. 4. Each session will consist of four sets: 30 repetitions in the first set and 15 repetitions in sets 2-4. 5. Rest intervals of 30 seconds will be provided between sets, during which the blood-flow-restriction device will remain in place.
Sponsors
Kaohsiung Veterans General Hospital.
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
55 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
\- 1. age 55 to 75 years. 2\. Diagnosed with moderate knee traumatic arthritis (Kellgren-Lawrence classification II or III)(experimental group). The control group must not have a diagnosis of osteoarthritis of the knee and must have normal knee joint function. 3\. Physical Health Status: Able to perform basic movements requiring isometric knee contraction tests and electromyography recording. 4\. Able to wear knee orthotics.
Exclusion criteria
* 1\. Knee or lower extremity injury: Recent (within the past 6 months) history of severe injury, fracture, or surgery to the knee or lower extremity. 2\. Other joint disorders: Coexisting joint disorders (such as rheumatoid arthritis or gouty arthritis). 3\. Neuromuscular disorders: Presence of neuromuscular dysfunction, such as stroke, Parkinson's disease, or peripheral neuropathy. 4\. Uncontrolled cardiovascular disease, hypertension, diabetes, or other medical conditions. Taking medications that affect neuromuscular function. 5\. Allergy or intolerance: Allergy to laboratory equipment (such as electromyography electrode gel) or knee brace materials.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| maximal voluntary isometric contraction (MVC) | Baseline and 3 weeks | — |
| The Western Ontario and McMaster Universities Turkish (WOMAC) index | baseline, 3 weeks | a self-administered questionnaire that assesses three aspects of a patient's health status -pain, stiffness, and physical function - in those with lower limb Osteoarthritis. WOMAC consists of 24 questions, with a total score ranging from 0 to 96 points. there are three subscales: pain (5 questions), stiffness (2 questions), and physical function (17 questions). a five-tier classification of symptomatic severity: minimal or no symptoms (≤24 score), mild (25-41 score), moderate (42-69 score), severe (70-86 score), and extreme (≥87 score). |
| The Knee Injury and Osteoarthritis Outcome Score (KOOS) | Baseline and 3 weeks | a knee-specific instrument, developed to assess the patients' opinion about their knee and associated problems. Knee Injury and Osteoarthritis Outcome Score (KOOS) has five subscales: pain (9 questions), symptoms (7 questions), activities of daily living (17 questions), sport/recreation (5 questions), knee-related quality of life (4 questions). The total score of each question (0-4 points) is converted into a score of 0-100, where 100 points represents the best knee health and 0 points represents the worst. |
| Motor Unit Recruitment (amplitude relative to recruitment threshold) | Baseline and 3 weeks | surface EMG decomposition |
| Motor Unit Recruitment (firing rate relative to recruitment threshold) | Baseline and 3 weeks | surface EMG decomposition |
Outcome results
None listed