Trismus
Conditions
Brief summary
This randomized controlled trial was conducted to compare the effect of serratiopeptidase versus no intervention on postoperative mouth opening, swelling, and trismus following surgical removal of mesioangular mandibular third molars.
Detailed description
A total of 110 patients undergoing surgical extraction of mesioangular mandibular third molars were randomly assigned into two groups. Group A received serratiopeptidase postoperatively, while Group B received no enzyme therapy. Mouth opening was measured postoperatively and compared between the two groups to assess the effectiveness of serratiopeptidase in reducing trismus and postoperative swelling.
Interventions
Serratiopeptidase was administered postoperatively following surgical removal of a mesioangular mandibular third molar as an adjunct to standard postoperative care to reduce postoperative pain, swelling, and inflammation.
Routine postoperative management following surgical removal of a mesioangular mandibular third molar without serratiopeptidase, including prescribed analgesics, antibiotics if indicated, and postoperative instructions.
Sponsors
Sharif Medical Research Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
\- Patients aged 18 to 40 years. Patients requiring surgical removal of a mesioangular impacted mandibular third molar. Patients who are systemically healthy (ASA I or II). Patients willing to participate and provide written informed consent. Patients who can comply with postoperative follow-up visits.
Exclusion criteria
* Patients with systemic diseases affecting healing (e.g., diabetes, immunocompromised state). Pregnant or lactating women. Patients with known allergy or hypersensitivity to serratiopeptidase. Patients on long-term anti-inflammatory or steroid medication. Presence of acute infection at the surgical site. Patients who have taken anti-inflammatory drugs within 48 hours before surgery.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative Facial Swelling | Postoperative Day 1, Day 3, and Day 7 | Change in facial swelling measured using standardized facial measurements between fixed anatomical landmarks following surgical removal of a mesioangular mandibular third molar, comparing the serratiopeptidase group and the control group. |
Countries
Pakistan
Outcome results
None listed