Neurodevelopmental Disorders
Conditions
Keywords
Sensory, Neurophysiology, Profile
Brief summary
The goal of this observational study is to evaluate intra-individual neurophysiological variability in children and adults with and without NeuroDevelopmental Disorders (NDD), for several sensory modalities and types of stimulation. The main hypotheses are: * NDD participants and children exhibit higher intra-individual variability than other participants * intra-individual neurophysiological variability is correlated to behavioral, psychological and learning profiles Participants in this study will: * be recorded for EEG and other neurophysiological parameters while exposed to sensory stimulations, to quantify sensory neurophysiological variability * perform behavioral tests and fill out questionnaires, to establish the behavioral and psychological profile * train for perceptual learning, to measure learning abilities These evaluations will be split in 3 visits spread on a maximum of 3 months, and training for learning will be done at home in between 2 visits.
Interventions
None listed
Sponsors
University Hospital, Tours
Institut National de la Santé Et de la Recherche Médicale, France
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
6 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Social security affiliation * Free and written informed consent from the participants (Neurotypical Adults, NDD Adults without judicial protective measures), or their tutor or legal representant(s) (other participants) * Age between 6 and 12 years included (Children) or between 18 and 45 years included (Adults) * For NDD participants: NDD diagnosis by a qualified medical professional, according to DSM-4, DSM-5, ICD-10 or ICD-11 criteria Non-inclusion Criteria: * Psychotropic medication perturbing EEG recording * Drugs pertubing peripheral neurophysiological measures * Non-corrected visual or auditory troubles * Known neurological or psychiatric conditions (at the exclusion of NDD for NDD participants) * Epilepsy * Inclusion in another ongoing medical protocol * For Neurotypical participants: NDD diagnosis * For NDD participants: anticipated psychological or physical risk at participating, at the investigator's discretion
Exclusion criteria
* Participants with no data to evaluate Outcome 1
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Amplitude of central neurophysiological responses to sensory stimulations | Through study completion, an average of 2 months per participant | Amplitude (in micro-volts) of event-related potentials |
| Latency of central neurophysiological responses to sensory stimulations | Through study completion, an average of 2 months per participant | Latency (in milli-seconds) of event-related potentials |
| Variability of central neurophysiological responses to sensory stimulations | Through study completion, an average of 2 months per participant | Intra-individual variability (in percentage) of event-related potentials |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Visual perceptual learning performance | Through study completion, an average of 2 months per participant | Discrimination performance (in percentage) for visual delayed-matching to sample task |
| Auditory perceptual learning performance | Through study completion, an average of 2 months per participant | Discrimination performance (in percentage) for auditory delayed-matching to sample task |
| Behavioral sensory profile | Through study completion, an average of 2 months per participant | Score (in absolute score) for psychomotor evaluation (Échelle des Particularités Sensori-psychomotrices dans l'Autisme) |
| Sensory profile questionnaire | Through study completion, an average of 2 months per participant | Score (in absolute score) for sensory questionnaire (Dunn Sensory Profile) |
| Cognitive psychological profile | Through study completion, an average of 2 months per participant | Score (in absolute score) for cognitive test (Raven's Progressive Matrices) |
| Executive functions questionnaire | Through study completion, an average of 2 months per participant | Score (in absolute score) for executive functions questionnaire (BRIEF or BRIEF-A depending on the group) |
| Attentional functions questionnaire | Through study completion, an average of 2 months per participant | Score (in absolute score) for attentional functions questionnaire (SNAP-IV-26 or ASRS-V1.1 depending on the group) |
| Socio-emotional questionnaire | Through study completion, an average of 2 months per participant | Score (in absolute score) for socio-emotional questionnaire (AQ) |
| Linguistic profile | Through study completion, an average of 2 months per participant | Score (in absolute score) for non-words and sentences repetition (LITMUS) |
| Heart beat response to sensory stimulations | Through study completion, an average of 2 months per participant | Heart beat variation (in milliseconds) following sensory stimulation, recorded simultaneously with EEG |
| Electrodermal activity response to sensory stimulations | Through study completion, an average of 2 months per participant | Electrodermal activity variation (in microsiemens) following sensory stimulation, recorded simultaneously with EEG |
| Pupillary response to sensory stimulations | Through study completion, an average of 2 months per participant | Pupillary diameter variation (in millimeter) following sensory stimulation,recorded simultaneously with EEG |
Countries
France
Contacts
CONTACTClaire WARDAK, Dr
CONTACTAdeline MOUSSET
Outcome results
None listed