Absence of Pathology on the CBCL and Ab-DIB for the Healthy Control Group, All Participants Were Euthymic at the Time of Task Administration, Diagnosis of ADHD Using the KSADS-PL for the ADHD Group, Diagnosis of BPD Based on the DIB-R Clinical Interview for the BPD Group
Conditions
Keywords
disturbances in social cognition, cognitive control associated, borderline personality disorder, neuroimaging in adolescent girls, child psychiatry
Brief summary
Impaired social cognition and cognitive control associated with borderline personality disorder (BPD) remain less explored. Recent Franco-Canadian study, has shown the feasibility of a neuroimaging tests in Quebec adolescents with BPD. This study aims to increase knowledgements related to neural correlates of BPD and clinical disorders.
Interventions
DIAGNOSTIC_TESTfunctional magnetic resonance imaging (fMRI)
Investigators used fMRI to compare patterns of regional brain activation between three groups of adolescents girls: Six female adolescents meeting criteria for BPD, 6 female adolescents meeting criteria of ADHD and 6 female adolescents without psychiatric disorder were recruited.
Sponsors
Etablissement Public de la Sante Mentale de la Somme
Centre Hospitalier Universitaire, Amiens
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
FEMALE
Age
12 Years to 17 Years
Healthy volunteers
Yes
Inclusion criteria
* Female adolescents meeting DIB-R criteria for BPD group * Female adolescents meeting kSADS-PL for ADHD group * Female adolescents without any psychologic disorders
Exclusion criteria
* Any medical history with head trauma, chronic neurologic disease, any contraindications for fRMI, claustrophobia or pregnancy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| MRI-Acquired Activation Mapping | 2 years | Establishment of activation maps by statistical analysis of local signal variations to locate functional regions essential to motor skills and language. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Feasibility of this study | 2 years | Pilot feasibility study with a small sample size |
Countries
France
Contacts
CONTACTMICHAEL MONET, PhD
CONTACTJean Marc GUILE, Professor
PRINCIPAL_INVESTIGATORJean Marc GUILE, Professor
EPSM de la Somme
Outcome results
None listed