Food Allergy in Infants
Conditions
Keywords
oral immunotherapy, OIT, egg
Brief summary
In children allergic to egg, oral immunotherapy (OIT) with egg may accelerate that the children grow out of the food allergy. Children than have a positive oral food provocation with egg with a low threshold, will be offered to start OIT. This means that the child have to ingest a small amount of egg every day. Once a year, the child will undergo a new oral food provocation to investigate if the child is still allergic to egg or not. The age of the children at time of this acquired tolerance will be compared with a historical cohort of children with egg allergy.
Detailed description
The aim of the study is to investigate if OIT with egg white can accelerate tolerance to egg in infants with provocation-verified allergy to egg and with a low threshold. The study is non-randomised. Children fulfilling the inclusion criteria will be offered OIT. The children will undergo an oral provocation once a year to detect development of tolerance to egg. Age at tolerance acquisition will be compared with a histical cohort of aged-matched children with allergy to egg and with a similar threshold at the diagnostic provocation
Interventions
OTHERlow-dose OIT egg
The children have to ingest a small specified amount of egg white every day. The amount will gradually increase, as the child becomes more and more tolerant to egg
Sponsors
Josefine Gradman
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
12 Months to 36 Months
Healthy volunteers
No
Inclusion criteria
* positive specific IgE to egg * positive oral provocation for egg * low threshold
Exclusion criteria
* uncontrolled astham treatment with biologics or immunsupressive drugs treatment with antihistamines
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Percentage of children who develops tolerance to egg per year | If the oral food provocation is negative (that is the child is still allergic to egg) the child will be re-provocated after 12 months. As long as the provocation is positive it will be repeated once a year for 5 years | Once a year the children will undergo an oral food provocation with egg to investigate if they have becomed tolerant to egg |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| specific IgE | baseline and through study completion, an average of 1 year | Measurement of specific IgE to egg in the blood |
Contacts
CONTACTJosefine Gradman, MD, PhD
STUDY_CHAIRJane Clemmensen, Professor
H.C.Andersens Børne- og Ungehospital, Odense University Hospital
Outcome results
None listed