Effects of Menstrual Cycle on Optic Nerve Sheath Diameter in Patients Undergoing Laparoscopic Gynecologic Surgery

The Effect of Menstrual Cycle Phase on Optic Nerve Sheath Diameter in Patients Undergoing Laparoscopic Gynecologic Surgery

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07539831

Enrollment

110

Registered

2026-04-20

Start date

2026-04-20

Completion date

2027-04-05

Last updated

2026-04-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Menstrual Cycle, Optic Nerve Sheath Diameter, Postoperative Nausea and Vomiting

Keywords

Optic Nerve Sheath Diameter, Laparoscopic Gynecologic Surgery, Mini-Mental State Examination, Verbal Descriptive Scale, Follicular Phase, Luteal Phase

Brief summary

This observational study aims to evaluate the effect of menstrual cycle phase on optic nerve sheath diameter (ONSD) in women undergoing elective laparoscopic gynecologic surgery. Patients will be grouped according to menstrual cycle phase as follicular or luteal. ONSD measurements will be performed perioperatively, and postoperative nausea and vomiting as well as postoperative cognitive function will also be assessed. The study is designed to investigate whether hormonal variations during the menstrual cycle are associated with differences in intracranial pressure reflected by ONSD measurements and postoperative outcomes

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 45 Years

Healthy volunteers

Inclusion criteria

* Female patients aged 18 to 45 years * Scheduled for elective laparoscopic gynecologic surgery * Menstrual cycle in the follicular phase or luteal phase * American Society of Anesthesiologists (ASA) physical status I-II

Exclusion criteria

* Irregular menstrual cycle (e.g., polycystic ovary syndrome, early menopause, hypothalamic amenorrhea) * Pregnancy or breastfeeding * Neurological disease associated with intracranial pressure changes * Glaucoma or another eye disease associated with high intraocular pressure * Previous brain surgery * Uncontrolled hypertension or severe cardiovascular disease

Design outcomes

Primary

Measure	Time frame	Description
Optic Nerve Sheath Diameter	Before induction of anesthesia, during surgery, and at the end of surgery	The primary outcome is the comparison of optic nerve sheath diameter (ONSD) between women in the follicular phase and those in the luteal phase of the menstrual cycle undergoing elective laparoscopic gynecologic surgery. ONSD will be measured ultrasonographically in the supine position. For each eye, three horizontal and three vertical measurements will be obtained and averaged.

Secondary

Measure	Time frame	Description
Postoperative Nausea and Vomiting	Within 24 hours after surgery	Postoperative nausea and vomiting will be assessed using the Verbal Descriptive Scale (VDS) and compared between the follicular-phase and luteal-phase groups. The VDS categories are none, mild, moderate, vomiting once, and severe vomiting.
Postoperative Cognitive Function	Preoperative period and 24 hours after surgery	Postoperative cognitive function will be assessed using the Mini-Mental State Examination (MMSE) and compared between the follicular-phase and luteal-phase groups.

Countries

Turkey (Türkiye)

Contacts

CONTACTMAHMUT TUTAR, MD

masatu42@gmail.com905552723704

CONTACTMAHMUT TUTAR, md

PRINCIPAL_INVESTIGATORMAHMUT TUTAR, MD

Konya City Hospital

Outcome results