Primary Angle-Closure Glaucoma
Conditions
Brief summary
Compared with primary angle-closure glaucoma (PACG) patients without zonular laxity and the control group, there are differentially expressed molecules in PACG patients with zonular laxity, and a potential mechanistic network can be constructed therefrom.
Detailed description
This study investigates the pathogenesis of PACG by conducting multi-omics analyses of aqueous humor, blood and anterior lens capsule samples from PACG patients with and without concomitant zonular abnormalities, aiming to elucidate the etiology of zonular abnormalities and uncover novel mechanisms underlying their involvement in the pathogenesis of glaucoma.
Interventions
OTHERNo Additional Experimental Intervention
No Additional Experimental Intervention
Sponsors
Zhongnan Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
50 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Clinically diagnosed with primary angle-closure glaucoma (PACG) * Aged ≥ 50 years, no gender restriction * Case Group A: Undergoing glaucoma surgery with intraoperatively confirmed significant zonular laxity * Case Group B: Undergoing glaucoma surgery with intraoperatively confirmed normal zonular morphology * Control group: age- and sex-matched with case groups; clinically diagnosed with age-related cataract; normal anterior chamber depth and angle; no history or signs of glaucoma; undergoing cataract surgery
Exclusion criteria
* Secondary glaucoma * History of previous intraocular surgery * Systemic diseases that can cause abnormal ocular zonules * Other severe ocular diseases * Long-term use of medications affecting connective tissue metabolism
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Concentration of differentially expressed molecules in PACG patients with zonular laxity | 2 years | Compared with primary angle-closure glaucoma (PACG) patients without zonular laxity and healthy control subjects, differentially expressed molecules will be identified and quantified by high-throughput omics sequencing and bioinformatics analysis in PACG patients with zonular laxity, and a potential mechanistic network will be constructed based on these molecular changes. |
Countries
China
Contacts
CONTACTMin Ke, doctor
CONTACTXiaomin Chen, doctor
STUDY_DIRECTORWen Zeng, doctor
Zhongnan Hospital
STUDY_DIRECTORNan Zhang, doctor
Zhongnan Hospital
PRINCIPAL_INVESTIGATORXuetian Yu, student
The Second Clinical College of Wuhan University
Outcome results
None listed