MRI, Functional MRI
Conditions
Keywords
Fmri, EEG
Brief summary
Cross modal correlation of EEG and MRI functional connectivity: An Investigative Study. Correlating EEG Analysis with Brain Network Connectivity in Functional MRI. The primary aim of this study is to correlate correlation of MRI and EEG.
Detailed description
Cross modal correlation of EEG and MRI functional connectivity: An Investigative Study. Correlating EEG Analysis with Brain Network Connectivity in fMRI. The primary aim of this study is to correlate correlation of MRI and EEG. The expected study duration is approximately 24 months (first patient in to last patient out). Estimated Enrolment: 1500 Subjects. The aim of this study is to correlate between fMRI and EEG. Overall, the integration of AI into the study of correlations between EEG and fMRI for brain network analysis holds great promise for advancing our understanding of brain function. Upon consent, eligible participants will be invited for EEG evaluation. EEG will be obtained using a dry electrodes headset. Correlation between fMRI and EEG connectivity for each EEG frequency band across different configurations (brain atlas, EEG connectivity measure). EEG data will undergo pre-processing of filtering, electrical line noise removal, artifact removal and down sampling. EEG analysis for each state, comprising within and between participant data, will include frequency analysis (peak frequency and relative power), oscillations (proportions of the activity of the alpha, beta, theta, and delta bands) and power spectra distribution. Functional connectivity analysis will be performed including functional coupling. For evoked response potentials analysis, data will be segmented to trials/epochs. Bad trials will be excluded from analysis. Included trials data will be averaged. Event-related synchronization (ERS) / desynchronization (ERD) will be evaluated.
Interventions
DIAGNOSTIC_TESTEEG
EEG uses small sensors paced on the scalp to record the brain's electrical activity.
Sponsors
Assaf-Harofeh Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Male or females aged 18 years or older. * Performed a brain MRI at the Sagol Center MRI Unit, at the Shamir Medical Center * Able to cooperate in an EEG evaluation * Can read and sign the informed consent.
Exclusion criteria
* Any scalp/bone abnormality incompatible with the EEG electrodes * Any known allergy to metals. * Inability to cooperate with simple instructions. * Inability to read and sign the informed consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Correlation of fMRI and EEG functional connectivity. | The expected study duration is approximately 24 months (first patient in to last patient out) | Examines how brain connectivity patterns measured by fMRI (blood-flow activity) relate to connectivity patterns measured by EEG (electrical activity). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between EEG to anatomical MRI findings | The expected study duration is approximately 24 months (first patient in to last patient out) | Investigates how electrical brain activity (EEG) corresponds to structural brain features or abnormalities seen on anatomical MRI. |
| Correlation between EEG to clinical diagnosis, cognitive and physical parameters. | The expected study duration is approximately 24 months (first patient in to last patient out) | Explores how EEG findings relate to a patient's medical diagnosis, cognitive functioning (e.g., memory, attention), and physical/neurological condition. |
Countries
Israel
Contacts
CONTACTShai Efrati, MD
PRINCIPAL_INVESTIGATORShai Efrati, MD
Study Principal Investigator
Outcome results
None listed