Non Small Cell Lung Cancer
Conditions
Brief summary
The goal of this observational study is to evaluate whether confocal laser endomicroscopy (CLE) can improve the real-time diagnosis of non-small cell lung cancer (NSCLC) in patients undergoing bronchoscopic biopsy for suspected lung tumors. The main questions it aims to answer are: * Can a high-specificity CLE-based score accurately identify NSCLC during endoscopic procedures? * Can CLE imaging criteria improve biopsy yield and help differentiate histological subtypes (e.g., squamous cell carcinoma, adenocarcinoma, carcinoid tumors)? Participants will: * Undergo standard bronchoscopic navigation procedures with additional real-time imaging using CLE and biopsy * Have CLE findings compared with standard histopathological analysis of biopsy samples
Interventions
PROCEDUREbronchoscopic navigation with CLE
bronchoscopic navigation with real-time imagine (Confocal Laser Endomicroscopy)
Sponsors
Central Hospital, Nancy, France
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Patient for whom endobronchial navigation-guided biopsy is indicated * Complete medical data (CLE images and histopathological results)
Exclusion criteria
* Persons referred to in Articles L. 1121-5, L. 1121-7, and L. 1121-8 of the French Public Health Code: * Individuals under 18 years of age * Adult persons subject to legal protection measures (guardianship, curatorship, or judicial protection) * Adult persons unable to express their consent * Persons deprived of liberty by judicial or administrative decision, and persons receiving psychiatric care under Articles L. 3212-1 and L. 3213-1
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Diagnostic accuracy of the CLE-based score for non-small cell lung cancer (NSCLC) detection | During the endoscopic procedure and confirmed after biopsy analysis (up to 7 days) | Proportion of cases in which the CLE imaging score correctly identifies NSCLC, using standard histopathology from biopsy samples as the reference standard |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Improvement of biopsy yield using CLE imaging criteria | During the endoscopic procedure and confirmed after pathology analysis (up to 7 days) | Proportion of biopsy samples considered adequate for histopathological diagnosis when guided by CLE imaging features. |
| Identification of NSCLC histological subtypes using CLE imaging | During the procedure and confirmed after biopsy analysis (up to 7 days) | Accuracy of CLE imaging criteria in differentiating NSCLC subtypes (e.g., squamous cell carcinoma, adenocarcinoma, carcinoid tumors) compared with standard histopathology. |
Countries
France
Contacts
CONTACTLucie Schnedecker
Outcome results
None listed