Knee Osteoarthritis
Conditions
Keywords
music, rhythmic auditory stimulation, knee pain
Brief summary
The purpose of this research study is to compare muscle activation, changes in pain sensitivity, and brain function, between different walking conditions, including walking to music, walking to metronome, and walking without music or metronome.
Detailed description
Participants with knee osteoarthritis (OA) will complete a single study visit which will include three walking tasks, each being 25 minutes in duration. The walking tasks will include walking without music or metronome, walking to metronome, and walking with music. Participants muscle activity, brain activity, and movements will be recorded during these tasks. Participant's pressure pain threshold will be recorded at the beginning and after each task.
Interventions
BEHAVIORALRhythmic Auditory Stimulation with music
Walking to rhythmic Auditory Stimulation with music
BEHAVIORALRhythmic Auditory Stimulation with metronome
walking to rhythmic Auditory Stimulation with metronome
BEHAVIORALControl
Walking to no music or metronome
Sponsors
Boston University Charles River Campus
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
50 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Have activity related pain * Experience morning knee stiffness ≤ 30 minutes * Knee pain on most days for 3 months or more * Able to walk at least 20 minutes with assistance * Average overall knee pain severity of ≥= 4 on a 11-point numeric rating scale during previous week * BMI ≤ 40 * Able to communicate using English at a level to understand the study procedures and informed consent
Exclusion criteria
* Contraindications to exercise * Joint replacement in either hip, knee, or ankle * History of other disease that may involve the index joint including inflammatory joint disease such as rheumatoid arthritis, seronegative spondyloarthropathy (eg, ankylosing spondylitis, psoriatic arthritis, inflammatory bowel disease related arthropathy), crystalline disease (eg, gout or pseudogout), lupus erythematosus, knee joint infections, Paget's disease affecting the knee, or knee joint tumors. * Previous knee osteotomy in either knee * Other health conditions that impact motor functioning or prevent participation (e.g., stroke, Parkinson's disease, Alzheimer's disease, Multiple Sclerosis, diabetic neuropathy, etc.) * Corticosteroid or hyaluronic acid injections in either knee in the previous 3 months * Pregnancy (self-report) * Suspected or known drugs or alcohol abuse * Mini-mental State Examination (MMSE) score \< 24 * Hearing impairments * Pain in lower back or legs that is greater than knee pain
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Exercise-Induced Hypoalgesia (EIH) | Baseline | Change in pressure pain threshold (PPT) from baseline to after each walking task |
| medial quadriceps - medial hamstrings muscle coactivation | Baseline | Medial quadriceps-medial hamstrings muscle co-activation in each walking task will be assessed using surface electromyography |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Medial quadriceps- medial gastrocnemius muscle coactivation | Baseline | Medial quadriceps-medial gastrocnemius muscle co-activation in each walking task will be assessed using surface electromyography |
| lateral quadriceps- lateral hamstrings muscle coactivation | Baseline | Lateral quadriceps-lateral hamstrings muscle co-activation in each walking task will be assessed using surface electromyography |
| lateral quadriceps - lateral gastrocnemius muscle coactivation | Baseline | Lateral quadriceps-lateral gastrocnemoius muscle co-activation in each walking task will be assessed using surface electromyography |
Contacts
CONTACTDeepak Kumar, PT, PhD
CONTACTYiwen Yang, DPT
PRINCIPAL_INVESTIGATORDeepak Kumar, PT, PhD
Boston University Charles River Campus
Outcome results
None listed