Effects of Sleep Quality on Functional and Cognitive Outcomes in Multiple Sclerosis

Effects of Sleep Quality on Cognitive Flexibility, Physical Activity, Body Awareness, and Reaction Time in Multiple Sclerosis

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07536503

Enrollment

Registered

2026-04-17

Start date

2026-05-01

Completion date

2026-08-01

Last updated

2026-06-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple Sclerosis

Keywords

Multiple Sclerosis, Sleep Quality, Cognitive Flexibility, Physical Activity, Reaction Time, Body Awareness

Brief summary

The goal of this observational study is to investigate the effects of sleep quality on cognitive flexibility, physical activity level, body awareness, and reaction time in individuals with Multiple Sclerosis. The main question it aims to answer is: Does sleep quality influence cognitive flexibility, physical activity level, body awareness, and reaction time in individuals with Multiple Sclerosis? Researchers will compare individuals with good and poor sleep quality to determine whether differences in sleep quality result in variations in cognitive and physical performance outcomes. Participants will complete standardized assessments of sleep quality, cognitive flexibility, physical activity, and body awareness, and will perform a computer-based reaction time test. In addition, participants will wear a wearable activity tracker for 7 days to objectively measure physical activity levels.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Age between 18 and 65 years * Diagnosis of Multiple Sclerosis * Montreal Cognitive Assessment (MoCA) score ≥24 * Expanded Disability Status Scale (EDSS) score between 0 and 6.5 * No relapse within the last 3 months * Voluntary participation with written informed consent

Exclusion criteria

* Presence of other neurological, psychiatric, or systemic diseases * Severe visual, auditory, or balance impairments * History of surgery within the last 6 months * Use of sleep medication or central nervous system-affecting drugs * Severe orthopedic deformity or pain

Design outcomes

Primary

Measure	Time frame	Description
Sleep Quality (Pittsburgh Sleep Quality Index)	Baseline	Sleep quality will be assessed using the Pittsburgh Sleep Quality Index. Total scores range from 0 to 21, with higher scores indicating poorer sleep quality.
Cognitive Flexibility (Stroop Test, TBAG Form)	Baseline	Cognitive flexibility will be evaluated using the Stroop Test TBAG Form. Test completion time and number of errors will be recorded; longer completion times and more errors indicate lower cognitive flexibility.
Physical Activity Level (International Physical Activity Questionnaire-Short Form)	Baseline	Physical activity level will be assessed using the International Physical Activity Questionnaire-Short Form. Total physical activity will be calculated in MET-min/week.
Physical Activity Level (Wearable Device)	7 days	Daily step count will be recorded using a wearable activity tracker. Average step count over 7 days will be calculated.
Body Awareness Questionnaire	Baseline	Body awareness will be evaluated using the Body Awareness Questionnaire. Higher scores indicate greater body awareness.
Reaction Time (computer-based reaction time test)	Baseline	Reaction time will be assessed using a computer-based reaction time system. Average response time to visual stimuli will be recorded, with shorter times indicating better reaction performance.

Countries

Turkey (Türkiye)

Contacts

CONTACTSüleyman Korkusuz, PhD

suleyman.korkusuz@atilim.edu.tr+905388675480

STUDY_CHAIRBüşra S Korkusuz

Ankara University

Outcome results