Endodotic Microbiota, Inflammatory Cytokines, Intracanal Medicaments
Conditions
Keywords
Intracanal medicaments, Endodontic infections, Inflammatory cytokines
Brief summary
The objective of this study is to investigate "clinically" the effectiveness of Oleanolic acid based intracanal medicament compared to the commonly used intracanal medicaments (Calcium hydroxide and Ledermix) on the levels of bacteria in root canals and inflammatory cytokines in the periradicular tissues of teeth with apical periodontitis.
Interventions
PROCEDURERoot canal treatment
Root canal treatments with administration of intracanal medicaments
Sponsors
Mansoura University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
1. Single rooted teeth with pulp necrosis and apical periodontitis. 2. The age ranges from 20 to 60 years.
Exclusion criteria
1. Patient receiving antibiotic treatment within the preceding 3 months. 2. Patient reporting systemic disease. 3. Teeth that can not be isolated with rubber dam. 4. Teeth with periodontal pockets deeper than 3 mm.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Relief of signs and symptoms of apical periodontitis | 1 Week | Absence of discomfort with percussion, Absence of inflammatory exudate from the root canal. |
| Decrease in bacterial count within the root canal. | 1 week | A sample will be taken from the canal to assess the decrease in bacterial count inside the root canal by the effect of intracanal medicament. |
| Decrease in interleukin TNF-alpha, IL-1 Beta and PG-E2 in the periapical tissues | 1 week | A sample will be taken from the periapical region to detect the effect of the intracanal medicaments in reducing inflammation and promoting healing in the periapical region. |
Countries
Egypt
Outcome results
None listed