Creatine Supplementation, Exercise Ergogenics
Conditions
Keywords
creatine monohydrate, High Intensity Interval Training, Cognitive, Reaction Time, Executive Function
Brief summary
This study evaluates whether 7-day creatine monohydrate supplementation affects cognitive function after high-intensity interval training (HIIT) in active young men. Twenty participants were assigned to one of four groups: placebo plus exercise, placebo without exercise, creatine 0.1 g/KgBW/day plus exercise, or creatine 0.3 g/KgBW/day plus exercise. Cognitive performance was measured before and after the intervention using visual reaction time, go/no-go visual reaction time, and Trail Making Tests A and B.
Detailed description
This study used a controlled pretest-posttest, four-arm interventional design to examine the effects of short-term creatine monohydrate supplementation on cognitive function after high-intensity interval training (HIIT) in active young men. Twenty participants were allocated into four groups: placebo plus exercise, placebo without exercise, creatine 0.1 g/KgBW/day plus exercise, and creatine 0.3 g/KgBW/day plus exercise. The intervention lasted 7 days. Participants in the exercise groups completed a bodyweight HIIT protocol consisting of two rounds. Round 1 used 40 seconds of work and 20 seconds of rest, and round 2 used 30 seconds of work and 15 seconds of rest, with 30 seconds of rest between rounds. The session included 14 sequential movements and was preceded by a 5-minute warm-up and followed by a 5-minute cool-down. Cognitive performance was assessed before and after the intervention using visual reaction time (VRT), go/no-go visual reaction time (GNGVRT), and Trail Making Test Parts A and B. These measures were selected to capture processing speed, inhibitory control, attention, and executive function. The study was approved by the ethics committee of Universitas Negeri Malang, and written informed consent was obtained from all participants.
Interventions
DRUGCreatine Monohydrate
Creatine monohydrate supplementation at a dose of 0,1 g/KgBW/day for 7 days.
DRUGPlacebo
Placebo supplementation for 7 days
BEHAVIORALHigh Intensity Interval Training
A bodyweight high-intensity interval training program performed in 2 rounds with 40 seconds work and 20 seconds rest in round 1, and 30 seconds work and 15 seconds rest in round 2, with 30 seconds rest between rounds.
Sponsors
Universitas Negeri Malang
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
Participants were assigned to one of four parallel groups: placebo plus exercise, placebo without exercise, creatine 0.1 g/KgBW/day plus exercise, and creatine 0.3 g/KgBW/day plus exercise.
Eligibility
Sex/Gender
MALE
Age
19 Years to 25 Years
Healthy volunteers
Yes
Inclusion criteria
* Male sport science students aged 19 to 25 years * Physically active and accustomed to high-intensity exercise * Healthy volunteers * Willing to participate and provide written informed consent * Willing to complete the 7-day intervention and cognitive testing procedures
Exclusion criteria
* History of cardiovascular disease * History of kidney disease * Current use of creatine supplements * Current use of pre-workout supplements, steroids, or diuretics * Any musculoskeletal, neurological, or medical condition that could interfere with exercise participation or cognitive testing * Refusal or inability to complete the study procedures
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Go/No-Go Visual Reaction Time False Alarm Errors | Baseline and Day 7 | Number of false alarm (commission) errors recorded during the Go/No-Go Visual Reaction Time test. Lower values indicate better inhibitory control. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Go/No-Go Visual Reaction Time | Baseline and Day 7 | Average response time for correct go trials during the Go/No-Go Visual Reaction Time test, expressed in milliseconds. Lower values indicate faster processing speed. |
| Trail Making Test Part B Completion Time | Baseline and Day 7 | Trail Making Test Part B Completion Time |
| Visual Reaction Time | Baseline and Day 7 | Simple visual reaction time measured in milliseconds. Lower values indicate faster processing speed. |
| Trail Making Test Part A Completion Time | Baseline and Day 7 | Trail Making Test Part A Completion Time |
Countries
Indonesia
Outcome results
None listed