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Effect of PENG Block on Postoperative Tramadol Consumption in Partial Hip Prosthesis Surgery

Comparison of Postoperative Tramadol Consumption, Clinical Effects, and Side Effects in Patients With and Without PENG (Pericapsular Nerve Group) Block in Partial Hip Prosthesis Surgery

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07534137
Acronym
PENG-PKP
Enrollment
48
Registered
2026-04-16
Start date
2022-03-01
Completion date
2022-12-01
Last updated
2026-04-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hip Fracture, Postoperative Pain

Keywords

peng block, Pericapsular nerve group block, Hip surgery, Postoperative pain, Tramadol consumption, Regional anesthesia

Brief summary

This study aims to evaluate the effect of ultrasound-guided pericapsular nerve group (PENG) block on postoperative tramadol consumption, pain scores, and clinical outcomes in patients undergoing partial hip prosthesis surgery. Patients aged 18-75 years scheduled for surgery under general anesthesia were divided into two groups: those receiving PENG block and those not receiving the block. Postoperative tramadol consumption within the first 24 hours, visual analog scale (VAS) and numeric rating scale (NRS) scores, hemodynamic parameters, additional analgesic requirements, and recovery characteristics were recorded and compared between groups. The findings of this study are expected to contribute to optimizing multimodal analgesia strategies in hip surgery.

Detailed description

Postoperative pain management in hip surgery remains a significant clinical challenge, particularly in elderly patients. Effective analgesia is essential to reduce opioid consumption, improve patient comfort, and enhance recovery. The pericapsular nerve group (PENG) block is a relatively new regional anesthesia technique that targets the articular branches of the femoral, obturator, and accessory obturator nerves, providing analgesia to the anterior hip capsule. This prospective study was conducted to compare the clinical effects of PENG block in patients undergoing partial hip prosthesis surgery under general anesthesia. A total of 48 patients aged between 18 and 75 years were included and divided into two groups: the PENG group (Group P), which received ultrasound-guided PENG block with 20 mL of 0.5% bupivacaine after induction of general anesthesia, and the control group (Group K), which received general anesthesia alone. Demographic data, intraoperative anesthetic requirements, and postoperative parameters were recorded. The primary outcome measure was total tramadol consumption within the first 24 hours after surgery. Secondary outcomes included postoperative pain scores (VAS and NRS), hemodynamic parameters (mean arterial pressure and heart rate), remifentanil consumption, need for additional analgesia, bispectral index (BIS) values, patient comfort score, modified Aldrete recovery score, Riker agitation-sedation scale, and incidence of complications such as nausea, vomiting, hypotension, hypertension, and arrhythmia. The results of this study are intended to evaluate the effectiveness of PENG block as a component of multimodal analgesia and to determine its impact on opioid consumption and postoperative recovery in patients undergoing hip surgery.

Interventions

PROCEDUREPENG Block

Ultrasound-guided pericapsular nerve group block performed with 20 mL of 0.5% bupivacaine after induction of general anesthesia.

PROCEDUREGeneral Anesthesia

Standard general anesthesia administered without regional nerve block.

Sponsors

University of Gaziantep
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Masking description

No masking was applied in this study.

Intervention model description

Participants were randomly assigned to two parallel groups: a PENG block group receiving ultrasound-guided pericapsular nerve group block after induction of general anesthesia, and a control group receiving general anesthesia alone.

Eligibility

Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No

Inclusion criteria

* Patients aged between 18 and 75 years * Patients scheduled for partial hip prosthesis surgery * Patients classified as ASA physical status I-III * Patients who provided written informed consent

Exclusion criteria

* Known allergy to local anesthetics * Coagulation disorders or anticoagulant therapy contraindicating regional anesthesia * Infection at the injection site * Severe systemic disease (ASA IV or higher) * Cognitive impairment preventing reliable pain assessment * Refusal to participate in the study

Design outcomes

Primary

MeasureTime frameDescription
Total Tramadol Consumption Within 24 Hours After Surgery24 hours postoperativelyTotal amount of tramadol (mg) consumed by patients during the first 24 hours after surgery.

Secondary

MeasureTime frameDescription
Postoperative VAS Pain Scores0, 10, 30, 60 minutes and 2, 4, 6, 12, 24 hours postoperativelyVisual Analog Scale (VAS) pain scores ranging from 0 to 10, where 0 indicates no pain and 10 indicates worst imaginable pain, measured at predefined postoperative time points.
Postoperative NRS Pain Scores0, 10, 30, 60 minutes and 2, 4, 6, 12, 24 hours postoperativelyNumeric Rating Scale (NRS) pain scores ranging from 0 to 10, where 0 indicates no pain and 10 indicates worst possible pain, measured at predefined postoperative time points.
Intraoperative Remifentanil ConsumptionIntraoperative periodTotal amount of remifentanil used during surgery.
Additional Analgesic Requirement24 hours postoperativelyRequirement for additional analgesic medication in the postoperative period.
Postoperative Complications24 hours postoperativelyIncidence of complications including nausea, vomiting, hypotension, hypertension, arrhythmia, and pruritus.

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 23, 2026