Coronary Microvascular Dysfunction (CMD)
Conditions
Brief summary
Some people experience chest pain and shortness of breath, but when they have tests, no blockages are found in their main heart arteries. The most common cause of symptoms is related to abnormalities in the small blood vessels, also known as 'small vessel angina' or Coronary Microvascular Dysfunction (CMD). Currently, the diagnosis of CMD requires additional measurements of blood flow in the heart vessel during a minimally invasive procedure known as a coronary angiogram. CMD affects many people and can lead to repeated hospital visits and a lower quality of life, and diagnosing the condition leads to better patient outcomes. However, there are still no widely available, proven treatments for this condition and therefore several patients remain symptomatic. This study aims to find better ways to treat CMD, especially by understanding how the heart uses energy and how this might relate to symptoms.
Interventions
DRUGEmpagliflozin 10mg OD
Drug
Sponsors
King's College London
Guy's and St Thomas' NHS Foundation Trust
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Angina with non-obstructive coronary arteries
Exclusion criteria
* Significant epicardial coronary stenoses * Inability to carry out bike exercise * Contra-indication to adenosine administration * Insulin usage with frequent hypoglycaemic episodes
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Myocardial Perfusion Reserve | 8 weeks | Perfusion Cardiac Magnetic Resonance Imaging |
Contacts
CONTACTHaseeb Rahman, MA BMBCh MRCP PhD
Outcome results
None listed